School of Medicine, Primary Health Care, University of Eastern Finland, Kuopio, Finland.
BMC Musculoskelet Disord. 2010 Jul 30;11:171. doi: 10.1186/1471-2474-11-171.
Metabolic syndrome (MetS) is increasingly common. Obesity has been suggested to associate with neck pain but prevalence of neck pain in subjects with MetS has not been studied. Aim of this study was to analyse the association between MetS and neck pain.
The study population consisted of 1294 middle-aged subjects in Pieksämäki, Finland. A total of 399 males and 500 females participated (69%). The mean age of both males and females was 46 years. Clinical and biochemical measurements were taken. The participants filled out a standard questionnaire. Psychological distress was assessed with the 12-item General Health Questionnaire (GHQ-12). Neck pain was defined as neck pain perceived daily. MetS was defined using National Cholesterol Education Program (NCEP) criteria. Statistical comparisons between the groups were performed using a bootstrap-type t-test or Chi-Square test. Risk ratios of having neck pain were calculated using generalised linear models with age, smoking, alcohol use, exercise and GHQ-12 score as covariates.
The prevalence of MetS was 33% in males and 29% in females. Neck pain was present in 11% (N = 42) of males and 19% (N = 93) of females (P < 0.001). The prevalence of neck pain was 7.9% (95% CI, 4.9% to 12%) among male subjects without MetS and 16% (95% CI, 10% to 23%) among those with MetS. The respective proportions among females were 16% (95% CI, 12% to 20%) and 25% (95% CI, 18% to 33%). The multivariate analysis showed an increased risk of neck pain in males with MetS (RR 2.1, 95% CI, 1.2 to 3.7, P = 0.010) and in females with MetS (RR 1.5, 95% CI, 1.0 to 2.1, P = 0.040).
MetS was associated with neck pain. This association was stronger in males, but the prevalence of neck pain was higher in females. Prospective studies should explore the potential causal association between neck pain and MetS and the potential common background factors of neck pain and MetS.
代谢综合征（MetS）越来越常见。肥胖被认为与颈部疼痛有关，但代谢综合征患者颈部疼痛的患病率尚未研究。本研究旨在分析代谢综合征与颈部疼痛之间的关系。
研究人群为芬兰皮克萨米基的 1294 名中年受试者。共有 399 名男性和 500 名女性参加（69%）。男性和女性的平均年龄均为 46 岁。进行了临床和生化测量。参与者填写了一份标准问卷。使用 12 项一般健康问卷（GHQ-12）评估心理困扰。颈部疼痛定义为每天感觉到的颈部疼痛。代谢综合征使用国家胆固醇教育计划（NCEP）标准定义。使用 bootstrap 型 t 检验或卡方检验对组间进行统计学比较。使用广义线性模型计算有颈部疼痛风险的风险比，以年龄、吸烟、饮酒、运动和 GHQ-12 评分作为协变量。
男性代谢综合征的患病率为 33%，女性为 29%。男性颈部疼痛的患病率为 11%（N=42），女性为 19%（N=93）（P<0.001）。无代谢综合征的男性中颈部疼痛的患病率为 7.9%（95%CI，4.9%至 12%），而有代谢综合征的男性中为 16%（95%CI，10%至 23%）。女性的相应比例分别为 16%（95%CI，12%至 20%）和 25%（95%CI，18%至 33%）。多变量分析显示，男性代谢综合征（RR 2.1，95%CI，1.2 至 3.7，P=0.010）和女性代谢综合征（RR 1.5，95%CI，1.0 至 2.1，P=0.040）患者颈部疼痛的风险增加。
代谢综合征与颈部疼痛有关。这种关联在男性中更强，但女性颈部疼痛的患病率更高。前瞻性研究应探讨颈部疼痛与代谢综合征之间潜在的因果关系，以及颈部疼痛和代谢综合征的潜在共同背景因素。
