Rubin J, Bryer J V, Moshal M G
S Afr Med J. 1977 Sep 24;52(14):562-4.
Administration of 2 mg flunitrazepam (Rohypnol; Roche) to patients before gastro-intestinal endoscopy caused significantly less anxiety and achieved significantly greater sedation than diazepam (Vallium; Roche). No differences were found between any of the trial groups with respect to ease of intubation, tolerance of the procedure, gastric peristalsis, and the state of the pylorus. Memory of the procedure was significantly less vivid in the groups who received 2 mg flunitrazepam, than in the other groups. The patients who received 2 mg flunitrazepam showed a significantly greater willingness to undergo a repeat procedure, both when asked immediately after the procedure, and when asked on the next visit. Pulse rate increased in all groups during the procedure. No change in respiratory rate or in systolic and diastolic blood pressure occurred in any group.
在胃肠内镜检查前给患者服用2毫克氟硝西泮（氟硝安定；罗氏公司）比服用地西泮（安定；罗氏公司）引起的焦虑明显更少，镇静效果明显更好。在插管的难易程度、对该操作的耐受性、胃蠕动以及幽门状态方面，各试验组之间均未发现差异。接受2毫克氟硝西泮的组对该操作的记忆明显不如其他组清晰。接受2毫克氟硝西泮的患者，无论是在操作后立即询问，还是在下次就诊时询问，都表现出明显更强的接受重复操作的意愿。在操作过程中所有组的脉搏率均升高。任何组的呼吸频率以及收缩压和舒张压均未发生变化。
