University of Michigan Program in Biomedical Sciences, Ann Arbor, MI, USA.
Transplantation. 2010 Dec 15;90(11):1139-44. doi: 10.1097/TP.0b013e3181efd018.
Transforming growth factor (TGF)-β is a pleiotropic cytokine with beneficial and detrimental effects posthematopoietic stem-cell transplantation. TGF-β is increased in specific sites postengraftment and can suppress immune responses and maintain peripheral tolerance. Thus, TGF-β may promote allograft acceptance. However, TGF-β is also the central pathogenic cytokine in fibrotic disease and likely promotes pneumonitis. Although TGF-β can enhance leukocyte recruitment and IgA production, it inhibits both innate and adaptive immune cell function and antiviral host defense posthematopoietic stem-cell transplantation. This review will focus on the current understanding of TGF-β biology and the numerous ways it can impact outcomes posttransplant.
转化生长因子 (TGF)-β 是一种多功能细胞因子，在造血干细胞移植后具有有益和有害的影响。TGF-β 在移植后特定部位增加，可抑制免疫反应并维持外周耐受。因此，TGF-β 可能促进同种异体移植物的接受。然而，TGF-β 也是纤维化疾病中的中心致病细胞因子，可能促进肺炎。尽管 TGF-β 可以增强白细胞募集和 IgA 产生，但它抑制造血干细胞移植后的先天和适应性免疫细胞功能和抗病毒宿主防御。本综述将重点介绍 TGF-β 生物学的现有认识，以及它在移植后对结果产生影响的多种方式。
