Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
J Dermatolog Treat. 2011 Dec;22(6):310-4. doi: 10.3109/09546634.2010.487889. Epub 2010 Aug 1.
Cutaneous tuberculosis is showing a resurgence. It continues to be one of the most elusive and difficult diseases to diagnose in dermatological practice. We sought to describe the clinical manifestations, laboratory features, and antituberculous therapy in cases of cutaneous tuberculosis. Twenty cases of cutaneous tuberculosis were observed in this study. Of the 20 cases, seven were in women (35%) and 13 were in men (65%). There were eight (40%) cases of lupus vulgaris, four (20%) cases of orificial tuberculosis, four (20%) cases of tuberculosis verrucosa cutis, two (10%) cases of scrofuloderma, and two (10%) cases of primary inoculation tuberculosis. In total, 20 strains of acid-fast bacilli were isolated by culture in Löwenstein-Jensen medium at 37°C. Mycobacterial species identification by polymerase chain reaction (PCR) assay showed that all strains were Mycobacterium tuberculosis. In vitro susceptibility testing by use of absolute concentration method showed that the 20 strains were sensitive to rifampin, ethambutol, and isoniazid; however, two strains were resistant to streptomycin. All of the patients responded favourably to antituberculous treatment. Cutaneous tuberculosis is a skin disease that should still be thought much of in mainland China, and in this study lupus vulgaris is the most common clinical presentation.
皮肤结核正在卷土重来。它仍然是皮肤科实践中最难以捉摸和最难诊断的疾病之一。我们旨在描述皮肤结核病例的临床表现、实验室特征和抗结核治疗。本研究观察了 20 例皮肤结核病例。20 例中，女性 7 例（35%），男性 13 例（65%）。其中 8 例（40%）为寻常狼疮，4 例（20%）为腔口结核，4 例（20%）为疣状皮肤结核，2 例（10%）为瘰疬，2 例（10%）为原发接种性结核。共从 Löwenstein-Jensen 培养基中 37°C 培养分离出 20 株抗酸杆菌。聚合酶链反应（PCR）检测鉴定分枝杆菌种显示所有菌株均为结核分枝杆菌。绝对浓度法体外药敏试验显示，20 株均对利福平、乙胺丁醇和异烟肼敏感；但有 2 株对链霉素耐药。所有患者对抗结核治疗反应良好。皮肤结核是一种在中国内地仍应高度重视的皮肤疾病，本研究中寻常狼疮是最常见的临床表现。
