Yap Felix Boon-Bin, Thevarajah Suganthi, Asmah Johar
Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Dermatol Online J. 2010 Jul 15;16(7):2.
Penicilliosis is a systemic fungal infection caused by Penicillium marneffei. The infection is most commonly seen in Southeast Asia, Southern China, Hong Kong, and Taiwan. It is rarely seen among individuals of African descent. Here, we report a case of penicilliosis in an African man from Namibia who was studying in Malaysia. He presented with multiple umbilicated papules associated with cough, fever, loss of appetite, and weight. He also had urethral discharge and admitted to unprotected sexual intercourse with multiple partners. Histopathological examination of a skin papule showed the presence of multiple 2 to 4 microm intracellular yeast cells. Culture of the papule revealed Penicillium marneffei. The serology for human immunodeficiency virus (HIV) was positive. This case illustrates the need to recognize penicilliosis in any individuals staying or travelling to Southeast Asia and the need to look for underlying HIV infection in adults with umbilicated papules.
马尔尼菲青霉病是一种由马尔尼菲青霉菌引起的全身性真菌感染。这种感染在东南亚、中国南部、香港和台湾最为常见。在非洲裔个体中很少见。在此，我们报告一例来自纳米比亚、在马来西亚求学的非洲男子患马尔尼菲青霉病的病例。他出现多个脐凹状丘疹，并伴有咳嗽、发热、食欲不振和体重减轻。他还有尿道分泌物，且承认与多个性伴侣有过无保护性行为。皮肤丘疹的组织病理学检查显示存在多个2至4微米的细胞内酵母细胞。丘疹培养显示为马尔尼菲青霉菌。人类免疫缺陷病毒（HIV）血清学检测呈阳性。该病例表明，对于任何在东南亚停留或前往东南亚的个体，都需要认识到马尔尼菲青霉病，并且对于有脐凹状丘疹的成年人，需要寻找潜在的HIV感染。
