Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, 1656 E Mabel St., Tucson, AZ 85719, USA.
Curr Opin Immunol. 2010 Aug;22(4):535-40. doi: 10.1016/j.coi.2010.06.011. Epub 2010 Jul 30.
Recent developments in the field of immune memory research and the accumulating literature on age-related alterations in homeostasis, primary and memory T cell responses make it pertinent to address whether and how memory responses are affected by aging with regard to their generation, maintenance, and protective function. New knowledge of T cell repertoire maintenance over long periods of time, particularly when confronted with persistent pathogen challenge, is now enriched further by studies on whether recent immunological memory can 'overfill' and/or constrict prior memory responses. Along with studies on potentiation of memory responses by dietary/metabolic interventions and the recent advances on regulation of primary responses with aging, these findings provide a platform for new approaches to vaccination of older adults.
近年来，免疫记忆研究领域取得了新的进展，有关衰老过程中稳态、初始和记忆 T 细胞反应变化的文献也日益增多，这使得人们有必要探讨衰老是否以及如何影响记忆反应的产生、维持和保护功能。现在，关于 T 细胞库在长时间内的维持，特别是在持续的病原体挑战下，新的知识进一步丰富了研究，即近期免疫记忆是否会“过充”和/或限制先前的记忆反应。此外，关于饮食/代谢干预对记忆反应的增强作用以及随着年龄增长对初始反应调节的最新进展，这些发现为老年人疫苗接种的新方法提供了平台。
