Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.
J Clin Immunol. 2011 Apr;31(2):137-46. doi: 10.1007/s10875-010-9499-x. Epub 2011 Jan 18.
The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.
免疫系统受衰老过程的影响，并经历显著的与年龄相关的变化，称为免疫衰老。不同的 T 细胞亚群受此过程影响。骨髓和胸腺内的改变导致 T 细胞库组成从幼稚 T 细胞向抗原经验 T 细胞转移，从而损害 T 细胞库的多样性。此外，潜伏病原体（如巨细胞病毒）的感染会加重这一过程。在这篇综述中，我们重点关注幼稚和抗原经验 T 细胞群体中发生的主要与年龄相关的变化。我们讨论了负责这些亚群产生和维持的机制，以及如何通过临床干预来延迟或预防与年龄相关的变化。
