Sobczyńska-Rak Aleksandra, Żylińska Beata, Polkowska Izabela, Szponder Tomasz
Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland
Department and Clinic of Animal Surgery, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.
In Vivo. 2018 May-Jun;32(3):507-515. doi: 10.21873/invivo.11268.
BACKGROUND/AIM: Paradontopathy and neoplasms of the oral cavity represent one of the greatest challenges in human and animal dentistry. EGF plays a key role in maintaining the integrity and proper rate of cell proliferation in normal oral epithelium. The aim of the present study was to study serum levels of EGF in dogs diagnosed with periodontal diseases and oral cavity tumours.
The samples comprised of cancerous tissue sections and serum obtained from dogs of various breeds, aged between 5-13 years. Serum EGF concentrations were measured by an immunoenzymatic method.
The median for EGF concentration in serum of dogs suffered from severe periodontal diseases was greater when compared to the control group. EGF concentration in dogs with malignant tumours was significantly higher than in those with non-malignant growths. A positive correlation between EGF concentration and tumour size was also observed. EGF level in dogs diagnosed with benign tumours was comparable to the control group.
The blood serum level of EGF increases significantly in patients with malignant oral tumours and advanced periodontal disease. In malignant tumours, the high level of EGF correlates with the size and invasiveness of the neoplasm.
背景/目的：牙周病和口腔肿瘤是人类和动物牙科领域面临的最大挑战之一。表皮生长因子（EGF）在维持正常口腔上皮细胞的完整性和适当的细胞增殖速率方面起着关键作用。本研究的目的是研究被诊断患有牙周疾病和口腔肿瘤的犬血清中EGF的水平。
样本包括取自5至13岁不同品种犬的癌组织切片和血清。血清EGF浓度采用免疫酶法测定。
与对照组相比，患有严重牙周疾病的犬血清中EGF浓度的中位数更高。患有恶性肿瘤的犬的EGF浓度显著高于患有非恶性肿瘤的犬。还观察到EGF浓度与肿瘤大小之间呈正相关。被诊断患有良性肿瘤的犬的EGF水平与对照组相当。
患有恶性口腔肿瘤和晚期牙周病的患者血清中EGF水平显著升高。在恶性肿瘤中，高水平的EGF与肿瘤的大小和侵袭性相关。
