Department of Cell and Developmental Biology and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Cytokine Growth Factor Rev. 2010 Aug;21(4):287-98. doi: 10.1016/j.cytogfr.2010.06.001. Epub 2010 Jul 31.
Genetic and functional studies indicate that common components of the bone morphogenetic protein (BMP) signaling pathway play critical roles in regulating vascular development in the embryo and in promoting vascular homeostasis and disease in the adult. However, discrepancies between in vitro and in vivo findings and distinct functional properties of the BMP signaling pathway in different vascular beds, have led to controversies in the field that have been difficult to reconcile. This review attempts to clarify some of these issues by providing an up to date overview of the biology and genetics of BMP signaling relevant to the intact vasculature.
遗传和功能研究表明，骨形态发生蛋白（BMP）信号通路的常见成分在调节胚胎血管发育以及促进成年期血管稳态和疾病方面发挥着关键作用。然而，体外和体内研究结果之间存在差异，以及不同血管床中 BMP 信号通路的独特功能特性，导致该领域存在难以调和的争议。本综述通过提供与完整血管相关的 BMP 信号生物学和遗传学的最新概述，试图澄清其中的一些问题。
