Department of Biomedical Engineering, University of California, Irvine, USA.
Lab Chip. 2010 Sep 21;10(18):2472-5. doi: 10.1039/c004737f. Epub 2010 Aug 2.
This paper presents a rapid, ultra-low-cost approach to fabricate microfluidic devices using a polyolefin shrink film and a digital craft cutter. The shrinking process (with a 95% reduction in area) results in relatively uniform and consistent microfluidic channels with smooth surfaces, vertical sidewalls, and high aspect ratio channels with lateral resolutions well beyond the tool used to cut them. The thermal bonding of the layers results in strongly bonded devices. Complex microfluidic designs are easily designed on the fly and protein assays are also readily integrated into the device. Full device characterization including channel consistency, optical properties, and bonding strength are assessed in this technical note.
本文提出了一种使用聚烯烃收缩膜和数字工艺切割机快速、超低成本制造微流控器件的方法。收缩过程（面积减少 95%）导致相对均匀和一致的微流道，具有光滑的表面、垂直的侧壁和高纵横比，其横向分辨率远远超过用于切割它们的工具。层的热键合导致器件具有较强的键合强度。复杂的微流控设计可以轻松地即时设计，并且蛋白质分析也可以很容易地集成到设备中。在本技术说明中评估了全器件特性，包括通道一致性、光学特性和键合强度。
