黑茶多酚降低了胆固醇在体外胶束中的溶解度和在大鼠肠道中的胆固醇吸收率。

Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats.

机构信息

Laboratory of Food and Biomolecular Science, Department of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 981-8555, Japan.

出版信息

J Agric Food Chem. 2010 Aug 11;58(15):8591-5. doi: 10.1021/jf1015285.

DOI:10.1021/jf1015285

PMID:20681647

Abstract

Administration of black-tea polyphenols (BTP) simultaneously reduced lymphatic recovery of both (3)H-cholesterol and (14)C-trioleoylglycerol in rats that were cannulated in the thoracic duct. BTP decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. When purified theaflavins, which are components of BTP, were used, theaflavin-monogallates (TFMGs), theaflavin-3-gallate (TF3G), and theaflavin-3'-gallate (TF3'G) were effective in eliminating cholesterol from bile salt micelles in vitro. Theaflavin (TF) and theaflavin-3,3'-digallate (TFDG) had no effect on the micellar solubility of cholesterol. The concentration of bile acid in the micelles was not influenced by the addition of any BTPs or theaflavins. These results suggest that the reduction of micellar cholesterol by BTP could be important to reducing cholesterol absorption.

摘要

给大鼠胸导管插管后同时给予黑茶多酚（BTP），可减少淋巴管中 3H-胆固醇和 14C-三油酰甘油的回收。BTP 呈剂量依赖性降低胆固醇在体外胶束中的溶解度。当使用 BTP 的成分茶黄素进行纯化时，茶黄素单没食子酸酯（TFMGs）、茶黄素-3-没食子酸酯（TF3G）和茶黄素-3'-没食子酸酯（TF3'G）可有效消除体外胆盐胶束中的胆固醇。茶黄素（TF）和茶黄素-3,3'-二没食子酸酯（TFDG）对胆固醇胶束的溶解度没有影响。添加任何 BTP 或茶黄素都不会影响胶束中胆汁酸的浓度。这些结果表明，BTP 降低胶束胆固醇的能力可能对降低胆固醇吸收很重要。