Department of Pharmacy, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Department of Stomatology, The 970th Hospital of the Joint Logistics Support Force, Yantai, China.
J Transl Med. 2024 Jan 23;22(1):96. doi: 10.1186/s12967-024-04888-3.
Periodontitis is a chronic oral inflammatory disease that seriously affects people's quality of life. The purpose of our study was to investigate the correlation between the systemic immune inflammation index (SII) and periodontitis by utilizing a large national survey. This will establish a reference for the early identification and management of periodontitis.
This study comprised the adult US population who participated in a national periodontitis surveillance project during the six years from 2009 to 2014. Through the utilization of univariate and multivariate weighted logistic regression, we investigated the correlation between the systemic immune inflammation index and periodontitis. Additionally, we employed sensitivity analyses to evaluate the robustness of our findings.
The study involved 10,366 participants with an average age of 51.00 years, of whom 49.45% were male (N = 5126) and 50.55% were female (N = 5240). The prevalence of periodontitis is estimated to be about 38.43% in the US adults aged 30 or older population. Our logistic regression models indicated a positive association between a SII higher than 978 × 10/L and periodontitis. The elder group (aged 50 or older) with SII higher than 978 × 10/L demonstrated a significant correlation with periodontitis in the fully adjusted model (Odds Ratio [OR] = 1.409, 95% Confidence Interval [CI] 1.037, 1.915, P = 0.022). However, there is no statistical difference among adults aged 30 to 50. The robustness of our findings was confirmed through sensitivity analyses.
Our study highlights that SII is associated with periodontitis in a nationally representative sample of US adults. And the SII is significantly associated with a high risk of periodontitis in individuals aged 50 or older.
牙周炎是一种慢性口腔炎症性疾病，严重影响人们的生活质量。我们的研究目的是利用一项大型全国性调查来探讨系统性免疫炎症指数（SII）与牙周炎之间的相关性。这将为牙周炎的早期识别和管理提供参考。
本研究纳入了 2009 年至 2014 年六年期间参加全国牙周炎监测项目的美国成年人。我们采用单变量和多变量加权逻辑回归分析方法，探讨了系统性免疫炎症指数与牙周炎之间的相关性。此外，我们还进行了敏感性分析以评估研究结果的稳健性。
本研究共纳入了 10366 名平均年龄为 51.00 岁的参与者，其中 49.45%为男性（N=5126），50.55%为女性（N=5240）。估计美国 30 岁及以上成年人中牙周炎的患病率约为 38.43%。我们的逻辑回归模型表明，SII 高于 978×10/L 与牙周炎之间存在正相关关系。SII 高于 978×10/L 的 50 岁及以上老年组在完全调整模型中与牙周炎显著相关（比值比[OR]为 1.409，95%置信区间[CI]为 1.037，1.915，P=0.022）。然而，30 至 50 岁的成年人中则没有统计学差异。敏感性分析证实了我们研究结果的稳健性。
我们的研究表明，SII 与美国成年人的牙周炎存在关联。SII 与 50 岁及以上人群患牙周炎的风险显著相关。
