Department Digestive Diseases, Rush University Medical Center, Chicago, IL 60612-3824, USA.
Alcohol. 2010 May;44(3):223-8. doi: 10.1016/j.alcohol.2009.10.019.
Alcohol consumption is a potential trigger for flare in inflammatory bowel disease (IBD) flare because of alcohol's pro-oxidant effects and its deleterious effects on gut barrier function. The association with alcohol consumption and IBD flare is unclear. To test this hypothesis, we evaluated the pattern of alcohol consumption and its self-reported effect on gastrointestinal (GI) symptoms in patients with IBD. We recruited 129 consecutive patients: 52 patients with Crohn's disease, 38 patients with ulcerative colitis, and 39 patients with irritable bowel syndrome (IBS). All the participants completed a validated questionnaire on disease activity (the Crohn's disease activity index or ulcerative colitis clinical activity index, respectively) validated questionnaires to quantify alcohol consumption by National Institute of Alcohol Abuse and Alcoholism criteria, and two structured questionnaires we designed to access patients' perception of the effect of alcohol on their GI symptoms and on overall GI symptom severity. The pattern of current, light, moderate, and heavy alcohol consumption in inactive IBD was similar to the general U.S. population. Specifically, of the 90 inactive IBD patients, 56 (62%) were current drinkers, compared with 61% in the general U.S. population. Of current drinkers, 75% of IBD (N=42) and 43% of IBS (N=9) reported a worsening of GI symptoms with alcohol consumption (P=.01); however, overall GI symptom severity did not differ when compared with quantity of alcohol consumed. Patients with inactive IBD drink alcohol in quantities similar to the general population. Current drinkers with inactive IBD are more likely to report worsening of GI symptoms with alcohol than current drinkers with IBS.
饮酒可能会诱发炎症性肠病（IBD）发作，这是因为酒精具有促氧化作用，并且会损害肠道屏障功能。目前，饮酒与 IBD 发作之间的关联尚不清楚。为了验证这一假说，我们评估了 IBD 患者的饮酒模式及其对胃肠道（GI）症状的自述影响。我们招募了 129 名连续患者：52 名克罗恩病患者，38 名溃疡性结肠炎患者和 39 名肠易激综合征（IBS）患者。所有参与者均完成了针对疾病活动度的有效问卷（分别为克罗恩病活动指数或溃疡性结肠炎临床活动指数）、经国家酒精滥用和酒精中毒研究所标准量化饮酒量的有效问卷，以及我们设计的两个结构化问卷，以评估患者对酒精对其 GI 症状和整体 GI 症状严重程度的影响的认知。在非活动期 IBD 中，目前、轻度、中度和重度饮酒的模式与美国一般人群相似。具体来说，在 90 名非活动期 IBD 患者中，56 名（62%）为当前饮酒者，而美国一般人群中的这一比例为 61%。在当前饮酒者中，75%的 IBD 患者（N=42）和 43%的 IBS 患者（N=9）报告称，饮酒后 GI 症状恶化（P=.01）；然而，与所消耗的酒精量相比，整体 GI 症状严重程度并无差异。非活动期 IBD 患者的饮酒量与一般人群相似。非活动期 IBD 的当前饮酒者更有可能报告饮酒后 GI 症状恶化，而 IBS 的当前饮酒者则较少。
