The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel.
Learn Mem. 2010 Aug 3;17(8):402-6. doi: 10.1101/lm.1820010. Print 2010 Aug.
An experience extending the persistence of a memory after training Aplysia californica with inedible food also allows a consolidated memory to become sensitive to consolidation blockers. Long-term (24 h) memory is initiated by 5 min of training and is dependent on protein synthesis during the first few hours after training. By contrast, a more persistent (48 h) memory is dependent on a longer training session and on a later round of protein synthesis. When presented 24 h after training, a 3-min training that produces no memory alone can cause a memory that would have persisted for only 24 h to persist for 48 h. After a 48 h memory has been consolidated, 3 min of training also makes the memory sensitive to a protein-synthesis inhibitor. These findings suggest that a function of allowing a consolidated memory to become sensitive to blockers of protein synthesis may be to allow the memory to become more persistent.
用不可食用的食物训练加利福尼亚海兔后，会延长记忆的持久性，这种体验也能使已巩固的记忆对巩固阻滞剂变得敏感。通过 5 分钟的训练即可启动长达 24 小时的记忆，并且该记忆在训练后最初几个小时内依赖于蛋白质合成。相比之下，更持久（48 小时）的记忆依赖于更长时间的训练以及稍后一轮的蛋白质合成。当在训练后 24 小时呈现时，单独进行 3 分钟的训练不会产生记忆，但会使原本只能持续 24 小时的记忆持续 48 小时。在巩固了 48 小时的记忆之后，3 分钟的训练也会使记忆对蛋白质合成抑制剂敏感。这些发现表明，使已巩固的记忆对蛋白质合成抑制剂敏感的一个功能可能是使记忆更持久。
