Krishnan Harini C, Gandour Catherine E, Ramos Joshua L, Wrinkle Mariah C, Sanchez-Pacheco Joseph J, Lyons Lisa C
Department of Biological Science, Florida State University, Tallahassee, FL.
Program in Neuroscience, Florida State University, Tallahassee, FL.
Sleep. 2016 Dec 1;39(12):2161-2171. doi: 10.5665/sleep.6320.
Insufficient sleep in individuals appears increasingly common due to the demands of modern work schedules and technology use. Consequently, there is a growing need to understand the interactions between sleep deprivation and memory. The current study determined the effects of acute sleep deprivation on short and long-term associative memory using the marine mollusk , a relatively simple model system well known for studies of learning and memory.
were sleep deprived for 9 hours using context changes and tactile stimulation either prior to or after training for the operant learning paradigm, learning that food is inedible (LFI). The effects of sleep deprivation on short-term (STM) and long-term memory (LTM) were assessed.
Acute sleep deprivation prior to LFI training impaired the induction of STM and LTM with persistent effects lasting at least 24 h. Sleep deprivation immediately after training blocked the consolidation of LTM. However, sleep deprivation following the period of molecular consolidation did not affect memory recall. Memory impairments were independent of handling-induced stress, as daytime handled control animals demonstrated no memory deficits. Additional training immediately after sleep deprivation failed to rescue the induction of memory, but additional training alleviated the persistent impairment in memory induction when training occurred 24 h following sleep deprivation.
Acute sleep deprivation inhibited the induction and consolidation, but not the recall of memory. These behavioral studies establish as an effective model system for studying the interactions between sleep and memory formation.
由于现代工作安排和技术使用的要求，个体睡眠不足似乎越来越普遍。因此，越来越需要了解睡眠剥夺与记忆之间的相互作用。本研究使用海生软体动物确定了急性睡眠剥夺对短期和长期联想记忆的影响，海生软体动物是一种相对简单的模型系统，在学习和记忆研究中广为人知。
在操作性学习范式（即学习食物不可食用，LFI）训练之前或之后，通过改变环境和触觉刺激使动物睡眠剥夺9小时。评估睡眠剥夺对短期记忆（STM）和长期记忆（LTM）的影响。
LFI训练前的急性睡眠剥夺损害了STM和LTM的诱导，持续影响至少持续24小时。训练后立即进行睡眠剥夺会阻碍LTM的巩固。然而，在分子巩固期之后进行睡眠剥夺并不影响记忆回忆。记忆障碍与处理引起的应激无关，因为白天接受处理的对照动物没有表现出记忆缺陷。睡眠剥夺后立即进行额外训练未能挽救记忆的诱导，但当在睡眠剥夺后24小时进行训练时，额外训练减轻了记忆诱导中的持续损害。
急性睡眠剥夺抑制了记忆的诱导和巩固，但不影响记忆回忆。这些行为学研究确立了海生软体动物作为研究睡眠与记忆形成之间相互作用的有效模型系统。
