Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
J Investig Med. 2010 Oct;58(7):849-58. doi: 10.231/JIM.0b013e3181efbc61.
A recent report demonstrated that a laboratory-grown neobladder tissue could be successfully used for cystoplasty in young patients with myelomeningocele who were otherwise healthy. This remarkable achievement portends well for the application of tissue engineering/regenerative medicine technologies to the treatment of end-organ failure due to a variety of causes (ie, congenital, acquired, age or disease related). Nonetheless, the broader clinical use of these groundbreaking technologies awaits improved understanding of endogenous regenerative mechanisms, more detailed knowledge of the boundary conditions that define the current limits for tissue repair and replacement in vivo, and the parallel development of critical enabling technologies (ie, improved cell source, biomaterials, bioreactors). This brief report will review a number of the most salient features and recent developments in this rapidly advancing area of medical research and detail some of our own experience with bladder and skeletal muscle regeneration and replacement as examples that highlight both the promise and challenges facing regenerative medicine/tissue engineering.
最近的一份报告表明，实验室培养的新膀胱组织可成功用于 otherwise healthy 的脑脊膜膨出年轻患者的膀胱扩大术。这一显著成就预示着组织工程/再生医学技术在治疗各种原因（即先天性、后天性、年龄或疾病相关）导致的终末器官衰竭方面具有广阔的应用前景。尽管如此，这些开创性技术的更广泛临床应用仍需要更好地了解内源性再生机制，更详细地了解定义目前体内组织修复和替代的边界条件的知识，以及并行开发关键使能技术（即改进的细胞来源、生物材料、生物反应器）。本简要报告将回顾这一快速发展的医学研究领域的一些最突出的特征和最新进展，并详细介绍我们自己在膀胱和骨骼肌再生和替代方面的一些经验，以此为例，突出再生医学/组织工程所面临的机遇和挑战。
