Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China.
Int J Biol Macromol. 2010 Oct 1;47(3):356-60. doi: 10.1016/j.ijbiomac.2010.05.022. Epub 2010 Jun 4.
Longan (Dimocarpus longan Lour.) is used as a traditional edible and medicinal material in China. In this paper, the effects of polysaccharides from longan pulp with ultrasonic extraction (UELP) on the radicals scavenging, immunity-modulatory and antitumor activities in S180 tumor mice models were investigated. UELP showed excellent scavenging activity on the hydroxyl radicals and a,a-diphenyl-1-picrylhydrazyl (DPPH) radicals, and obtained the almost complete scavenging effect. UELP with medium-dose (200mg/kg) and low-dose (100mg/kg) had potent immune-modulatory effects in S180 tumor mice model and exhibited significant effect on delayed-type hypersensitivity (DTH) response, macrophage phagocytosis and ConA-stimulated splenocyte proliferation as compared with model control treatment (p<0.01). The results still showed that UELP had great antitumor effects, and maximum inhibition rate was obtained at medium-dose and low-dose (200 and 100mg/kg).
桂圆（Dimocarpus longan Lour.）在中国被用作传统的食用和药用材料。本文研究了超声提取龙眼果肉多糖（UELP）对 S180 肿瘤小鼠模型中自由基清除、免疫调节和抗肿瘤活性的影响。UELP 对羟基自由基和 1,1-二苯基-2-三硝基苯肼（DPPH）自由基具有优异的清除活性，几乎能完全清除。与模型对照组相比，中剂量（200mg/kg）和低剂量（100mg/kg）的 UELP 对 S180 肿瘤小鼠模型具有较强的免疫调节作用，对迟发型超敏反应（DTH）反应、巨噬细胞吞噬作用和 ConA 刺激脾淋巴细胞增殖均有显著影响（p<0.01）。结果还表明，UELP 具有很强的抗肿瘤作用，在中剂量和低剂量（200 和 100mg/kg）时获得最大抑制率。
