Fuccillo D A, Madden D L, Castellano G A, Uhlig L, Traub R G, Mattson J, Krezlewicz A, Sever J L
Neurology. 1978 Jun;28(6):613-5. doi: 10.1212/wnl.28.6.613.
One hundred and eight multiple sclerosis (MS) patients and 108 matched controls were studied for antibody levels and cellular immune responses to several viruses. There were significant increases in the mean titers of complement fixation (CF) or hemagglutination inhibition (HI), and complement-mediated cytotoxicity (CMC) tests for measles antibodies in MS patients; there was no increase in antibody titers to herpesviruses 1 and 2, or cytomegalovirus (CMV). The direct migration inhibition (DMI) tests showed no difference between MS patients and controls for measles, CMV, herpesviruses 1 and 2, or vaccinia virus antigens. Lymphocyte-mediated cytotoxicity (LMC) tests showed no difference between patients and controls, using cultures infected with measles and CMV viruses. In a study of stimulation or blocking of the LMC response by serum or cerebrospinal fluid (CSF), no effect was found. Therefore, increased levels of measles antibody in serum were again demonstrated in MS patients, but there was no difference in these patients' cellular immunity to measles virus versus that of the controls, and there was no abnormality of cellular immunity against the other viruses tested.
对108例多发性硬化症（MS）患者和108例匹配的对照者进行了研究，以检测他们针对几种病毒的抗体水平和细胞免疫反应。MS患者中，麻疹抗体的补体结合（CF）或血凝抑制（HI）平均滴度以及补体介导的细胞毒性（CMC）试验均有显著升高；而针对单纯疱疹病毒1型和2型以及巨细胞病毒（CMV）的抗体滴度没有升高。直接迁移抑制（DMI）试验显示，MS患者和对照者在针对麻疹、CMV、单纯疱疹病毒1型和2型或痘苗病毒抗原方面没有差异。淋巴细胞介导的细胞毒性（LMC）试验显示，使用感染麻疹和CMV病毒的培养物时，患者和对照者之间没有差异。在一项关于血清或脑脊液（CSF）对LMC反应的刺激或阻断作用的研究中，未发现有影响。因此，再次证实MS患者血清中麻疹抗体水平升高，但这些患者对麻疹病毒的细胞免疫与对照者相比没有差异，并且针对其他测试病毒的细胞免疫也没有异常。
