多发性硬化症患者以及 HLA 匹配和不匹配的兄弟姐妹的麻疹抗体滴度。

Measles antibody titers in multiple sclerosis patients and HLA-matched and unmatched siblings.

作者信息

Visscher B R, Sullivan C B, Detels R, Madden D L, Sever J L, Terasaki P I, Park M S, Dudley J P

出版信息

Neurology. 1981 Sep;31(9):1142-5. doi: 10.1212/wnl.31.9.1142.

DOI:10.1212/wnl.31.9.1142

Abstract

Antibody titers to measles, cytomegalovirus, and herpesviruses 1 and 2 were compared for siblings of multiple sclerosis (MS) patients sharing two, one, and no histocompatibility antigen haplotypes with the case. Significant differences were observed only for measles. Titers were significantly lower in siblings sharing no haplotypes with the case. Within case-sibling pairs, the presence of HLA-A-A3 and/or B7 affected measles antibody titers more than the presence of MS. These findings suggest that the immune response to measles in these sibships is influenced by the presence of HLA-A-A3 and/or B7 as well as another familial factor.

摘要

对患有多发性硬化症（MS）的患者的兄弟姐妹进行了检测，比较了他们针对麻疹、巨细胞病毒以及1型和2型疱疹病毒的抗体滴度。这些兄弟姐妹与病例分别共享两个、一个和零个组织相容性抗原单倍型。仅在麻疹抗体滴度方面观察到显著差异。与病例无共享单倍型的兄弟姐妹的抗体滴度显著更低。在病例-兄弟姐妹对中，HLA-A-A3和/或B7的存在对麻疹抗体滴度的影响大于MS的存在。这些发现表明，在这些兄弟姐妹关系中，对麻疹的免疫反应受HLA-A-A3和/或B7以及另一个家族因素的影响。