奥克尼群岛和设得兰群岛的多发性硬化症。IV：病毒抗体滴度与病毒感染
Multiple sclerosis in the Orkney and Shetland Islands. IV: Viral antibody titres and viral infections.
作者信息
Poskanzer D C, Sever J L, Sheridan J L, Prenney L B
出版信息
J Epidemiol Community Health. 1980 Dec;34(4):258-64. doi: 10.1136/jech.34.4.258.
Abstract
A controlled serologic survey of antibody titres to 17 viruses was undertaken in multiple sclerosis patients in the Orkney and Shetland Islands. No consistent pattern of elevated antibody titre levels or the presence of antibody was noted in patients compared with two control groups. Because of the isolation of these islands, the mean age at acquisition of common childhood infections, including measles, was considerably older than that of inhabitants of Europe and the United States of America. The age of occurrence of varicella was consistently younger in patients than in controls. Of note is the fact that six patients had measles after the onset of MS. This study failed to incriminate any of the viruses tested in the aetiology of MS.
摘要
在奥克尼群岛和设得兰群岛的多发性硬化症患者中进行了一项针对17种病毒抗体滴度的对照血清学调查。与两个对照组相比，患者中未发现抗体滴度水平升高或抗体存在的一致模式。由于这些岛屿与世隔绝，包括麻疹在内的常见儿童期感染的获得平均年龄比欧洲和美利坚合众国居民的年龄大得多。水痘发病年龄在患者中始终比对照组年轻。值得注意的是，有6名患者在多发性硬化症发病后患上了麻疹。这项研究未能证明所检测的任何一种病毒与多发性硬化症的病因有关。
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