Strassman R J, Qualls C R, Lisansky E J, Peake G T
Department of Psychiatry, University of New Mexico, School of Medicine, Albuquerque.
Acta Endocrinol (Copenh). 1991 Jun;124(6):646-51. doi: 10.1530/acta.0.1240646.
Melatonin affects gonadal function in non-primate mammals. Confirmatory data in man are not available. We assessed melatonin's acute effects on luteinizing hormone secretion in 17 normal men. We studied these men in conditions of sleep in the dark, and sleep deprivation in bright light, dim light, and bright light combined with a physiologically relevant infusion of melatonin, while measuring blood levels of immunoreactive LH every 20 min for 7 h. We compared overnight LH secretion, and LH pulse frequency, amplitude, length, interval and area under the curve using a modification of the PULSAR peak identification program, among the four treatments. Areas under the curve for peaks in all three conditions of sleep deprivation were lower than in normal sleep. The presence or absence of melatonin had no additional effect. We conclude that acute suppression of melatonin does not affect LH pulse parameters in normal man, but that sleep deprivation may reduce the amount of LH secreted per pulse.
褪黑素影响非灵长类哺乳动物的性腺功能。目前尚无关于人类的确证数据。我们评估了褪黑素对17名正常男性促黄体生成素分泌的急性影响。我们在黑暗中睡眠、强光下睡眠剥夺、弱光下睡眠剥夺以及强光结合生理相关剂量褪黑素输注的条件下对这些男性进行研究，同时每20分钟测量一次免疫反应性促黄体生成素的血药浓度，持续7小时。我们使用PULSAR峰识别程序的改进版比较了四种治疗方法之间的夜间促黄体生成素分泌情况以及促黄体生成素脉冲频率、幅度、时长、间隔和曲线下面积。在所有三种睡眠剥夺条件下峰值的曲线下面积均低于正常睡眠。褪黑素的存在与否没有额外影响。我们得出结论，急性抑制褪黑素对正常男性的促黄体生成素脉冲参数没有影响，但睡眠剥夺可能会减少每个脉冲分泌的促黄体生成素量。
