Strassman R J, Peake G T, Qualls C R, Lisansky E J
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque 87131.
J Clin Endocrinol Metab. 1987 Nov;65(5):847-52. doi: 10.1210/jcem-65-5-847.
The role of the pineal hormone melatonin in human physiology is uncertain. Previous studies correlated plasma melatonin levels with several physiological parameters or determined the responses to pharmacological doses of melatonin during daylight hours. We established an acute model that is more rigorously physiological. Constant nocturnal bright light in sleep-deprived normal men resulted in low plasma melatonin levels throughout the night, in contrast to sleep in the dark and dim light sleep deprivation nights. Subsequently, melatonin was infused during bright light exposure to approximate physiological levels. Plasma GH and PRL measurements in these four conditions revealed an effect of sleep deprivation independent of the presence or absence of melatonin. A subsample of these men had an intermediate level of melatonin suppression with 500 lux light intensity, relative to those during sleep and bright light. The results suggest that melatonin has no acute modulatory effect on the secretion of these two sleep-related hormones.
松果体激素褪黑素在人体生理学中的作用尚不确定。先前的研究将血浆褪黑素水平与几个生理参数相关联，或在白天测定了对药理学剂量褪黑素的反应。我们建立了一个更严格符合生理学的急性模型。与在黑暗中睡眠以及昏暗灯光下睡眠剥夺的夜晚相比，睡眠剥夺的正常男性持续夜间强光照射导致整个夜间血浆褪黑素水平较低。随后，在强光照射期间输注褪黑素以使其接近生理水平。在这四种情况下对血浆生长激素（GH）和催乳素（PRL）的测量揭示了睡眠剥夺的影响，与褪黑素的存在与否无关。相对于睡眠和强光照射期间，这些男性的一个子样本在500勒克斯光照强度下具有中等程度的褪黑素抑制水平。结果表明，褪黑素对这两种与睡眠相关激素的分泌没有急性调节作用。
