Strassman R J, Peake G T, Qualls C R, Lisansky E J
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque.
Neuroendocrinology. 1988 Oct;48(4):387-93. doi: 10.1159/000125039.
Using a recently developed model for investigating the neuroendocrine role of melatonin in man, we studied melatonin's effect on the nocturnal secretion of thyrotropin and cortisol in 17 normal male volunteers. The model consists of sleep in the dark and all-night sleep deprivation in conditions of: bright light with and without a melatonin infusion, and dim light. We have improved our infusion paradigm so that levels of melatonin during infusion are now indistinguishable from those occurring during sleep in the dark or dim light sleep deprivation. Sleep deprivation per se raised TSH levels compared to normal sleep. However, the three conditions of sleep deprivation could not be distinguished from each other, which suggests that the suppression of TSH by sleep (or the stimulation of TSH by sleep deprivation) is not mediated by melatonin. Cortisol secretion was unaffected by sleep deprivation regardless of melatonin's presence or absence. However, a difference in the pattern of secretion of cortisol in the sleep condition in the early morning (compared to the sleep deprivation conditions) was noted. These data do not implicate melatonin in the acute regulation of TSH or cortisol in normal man. These data also provide a method of melatonin infusion that replicates the pattern and levels seen in sleep.
利用最近开发的一个用于研究褪黑素在人体中神经内分泌作用的模型，我们对17名正常男性志愿者中褪黑素对促甲状腺激素和皮质醇夜间分泌的影响进行了研究。该模型包括在黑暗环境中的睡眠以及在以下条件下的整夜睡眠剥夺：有或无褪黑素输注的强光环境，以及弱光环境。我们改进了输注模式，使得输注期间的褪黑素水平现在与黑暗睡眠或弱光睡眠剥夺期间出现的水平无法区分。与正常睡眠相比，睡眠剥夺本身会提高促甲状腺激素水平。然而，这三种睡眠剥夺条件彼此无法区分，这表明睡眠对促甲状腺激素的抑制作用（或睡眠剥夺对促甲状腺激素的刺激作用）不是由褪黑素介导的。无论有无褪黑素，皮质醇分泌均不受睡眠剥夺的影响。然而，注意到清晨睡眠状态下皮质醇的分泌模式（与睡眠剥夺状态相比）存在差异。这些数据并未表明褪黑素参与正常人体促甲状腺激素或皮质醇的急性调节。这些数据还提供了一种褪黑素输注方法，该方法可复制睡眠中观察到的模式和水平。
