Onakewhor J U E, Okonofua F E
Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Nigeria.
Afr J Reprod Health. 2009 Jun;13(2):97-108.
Concerted efforts have been made to combat HIV infection in Nigerian. By contrast, much less attention has been paid to hepatitis C viral (HCV) infection. These viruses have similar immuno-epidemiology. The objective of this study was to determine the prevalence of HCV/HIV dual infection among 269 antenatal attendees at the University of Benin Teaching Hospital in southern Nigeria. The study was prospective and cross-sectional and consisted of the analysis of the sera of the participants for anti-HCV and HIV antibodies using ELISA. The result showed that 1.86% samples were HCV antibodies positive while 8.30% were seropositive for HIV-1 antibodies. There were no cases of dual infections. The HIV positive women and their babies had antiretroviral therapy. We conclude that dual HCV/HIV infection in pregnancy in Nigeria may be uncommon but suggest multicenter studies to determine the national prevalence while initiating strategies for their prevention.
尼日利亚已齐心协力抗击艾滋病毒感染。相比之下,丙型肝炎病毒(HCV)感染受到的关注则少得多。这些病毒具有相似的免疫流行病学特征。本研究的目的是确定尼日利亚南部贝宁大学教学医院269名产前检查者中HCV/HIV双重感染的患病率。该研究为前瞻性横断面研究,包括使用酶联免疫吸附测定法(ELISA)分析参与者血清中的抗HCV和HIV抗体。结果显示,1.86%的样本抗HCV抗体呈阳性,而8.30%的样本HIV-1抗体呈血清阳性。没有双重感染的病例。HIV阳性的妇女及其婴儿接受了抗逆转录病毒治疗。我们得出结论,尼日利亚孕期HCV/HIV双重感染可能并不常见,但建议开展多中心研究以确定全国患病率,并同时启动预防策略。