Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Cancer Invest. 2010 Oct;28(8):813-9. doi: 10.3109/07357900903405918.
The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue.
One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression.
The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%.
MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.
本研究旨在比较匹配的肿瘤组织和正常组织中锰超氧化物歧化酶（MnSOD）的表达。
评估了 100 例肺癌标本和同一患者的配对正常肺实质中 MnSOD 的表达。
正常 MnSOD 表达的中位数为 42%，范围为 10%至 70%，明显高于肿瘤样本中 MnSOD 表达的中位数 18.8%，范围为 1.1%至 50%。
与匹配的正常肺组织相比，肺腺癌和鳞状细胞癌中 MnSOD 的表达显著降低。
