Irawan Budi, Labeda Ibrahim, Lusikooy Ronald Erasio, Sampetoding Samuel, Kusuma M Ihwan, Uwuratuw Julianus Aboyaman, Syarifuddin Erwin, Faruk Muhammad
Division of Digestive, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Division of Oncology, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Ann Med Surg (Lond). 2020 Sep 2;58:194-199. doi: 10.1016/j.amsu.2020.08.032. eCollection 2020 Oct.
The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. For that reason, this study aimed to assess the association between SOD and the variables analyzed in this study.
This study was observational study using a cross-sectional research design aimed to measure the association between SOD and staging as well as grade of differentiation in CRC incidence. The study was conducted in our institution from January until March 2018.
Statistical analyses of the data derived from the laboratory indicated that age and histopathological examination (TNM staging) had statistically significant correlation with SOD1 level. This significant correlation was proven from results of the statistical analyses of each variable at p = 0.039 (age) and p = 0.001 (TNM staging) respectively. Subsequent tests concerning the correlation between age and TNM staging on SOD1 level revealed that the study samples in the category of 30-49 age years old showed statistically significant correlation with SOD1 level with p = 0.009.
The increase of grade of differentiation was proportional to the increase of SOD1 level as antioxidant against cancer in CRC patients.
基于结直肠癌（CRC）患者分期及分化程度检查发现，其超氧化物歧化酶（SOD）水平升高仍是一个明显的临床问题。SOD水平在特定分期升高，而在特定分化程度时降低。因此，本研究旨在评估SOD与本研究中分析的变量之间的关联。
本研究为观察性研究，采用横断面研究设计，旨在测量CRC发病率中SOD与分期以及分化程度之间的关联。该研究于2018年1月至3月在我们机构进行。
实验室数据的统计分析表明，年龄和组织病理学检查（TNM分期）与SOD1水平具有统计学显著相关性。分别从各变量的统计分析结果在p = 0.039（年龄）和p = 0.001（TNM分期）得到了这种显著相关性的证明。随后关于年龄与TNM分期对SOD1水平相关性的测试表明，年龄在30 - 49岁类别中的研究样本与SOD1水平具有统计学显著相关性，p = 0.009。
在CRC患者中，分化程度的增加与作为抗癌抗氧化剂的SOD1水平的增加成正比。
