University of São Paulo, Av. Lineu Prestes 2565, São Paulo, SP, Brazil.
Cephalalgia. 2011 Feb;31(3):331-7. doi: 10.1177/0333102410380754. Epub 2010 Aug 6.
To investigate the association between cardiovascular risk-factor profile and migraine in the elderly, we evaluated a population sample of ageing men and women (65 years or more) living in a low-income area in the city of São Paulo, Brazil.
We investigated migraine status and cardiovascular profile from a baseline of 1450 participants (65-102 years of age) of the São Paulo Ageing & Health Study (SPAH), a longitudinal population-based study with low-income elderly in Brazil. The following age and sex-adjusted cardiovascular risk factors were analyzed: blood pressure, pulse pressure, serum total and high-density lipoprotein cholesterol, body mass index, smoking, history of hypertension, diabetes and the 10-year risk of myocardial infarction or coronary heart disease death based on the Framingham Risk Score.
The overall prevalence of migraine was 11.4%, and it was 3 times more frequent among women than men (15.3% vs 5.4%; P < 0.0001). Migraineurs were younger than non-migraineurs (mean age 70.6 years vs 72.1 years; P = 0.001, respectively). There was no statistically significant difference regarding the cardiovascular risk-factor profile after adjustment for age and sex among migraineurs and non-migraineurs. Only a decrease in the risk of hypertension among women (OR 0.58; 95% CI 0.38-0.90; P = 0.01) was also observed even after adjustment for age.
Overall, we did not find a worse cardiovascular risk profile among elderly migraineurs. An inverse association between hypertension and migraine in women warrants further investigation.
为了研究心血管危险因素谱与老年人偏头痛之间的关系，我们评估了巴西圣保罗市一个低收入地区的老年男性和女性（65 岁及以上）人群样本。
我们从巴西圣保罗老龄化和健康研究（SPAH）的 1450 名参与者（65-102 岁）的基线中调查了偏头痛状况和心血管特征，这是一项针对巴西低收入老年人的基于人群的纵向研究。分析了以下年龄和性别调整后的心血管危险因素：血压、脉压、血清总胆固醇和高密度脂蛋白胆固醇、体重指数、吸烟、高血压史、糖尿病和基于弗雷明汉风险评分的 10 年心肌梗死或冠心病死亡风险。
偏头痛的总体患病率为 11.4%，女性是男性的 3 倍（15.3%比 5.4%；P<0.0001）。偏头痛患者比非偏头痛患者年轻（平均年龄分别为 70.6 岁和 72.1 岁；P=0.001）。在校正年龄和性别后，偏头痛患者和非偏头痛患者的心血管危险因素谱没有统计学差异。仅观察到女性高血压风险降低（OR 0.58；95%CI 0.38-0.90；P=0.01），即使在校正年龄后也是如此。
总体而言，我们没有发现老年偏头痛患者的心血管风险状况更差。女性偏头痛与高血压之间的反比关系值得进一步研究。
