Brigham and Women's Hospital, USA.
Cephalalgia. 2012 Oct;32(13):991-7. doi: 10.1177/0333102412453954. Epub 2012 Jul 17.
Previous cross-sectional studies evaluating the relationship between diabetes prevalence and migraine status have found conflicting results. We examined the relationship between migraine and incident type 2 diabetes (T2D) in a cohort of adult women.
Prospective cohort study conducted among participants in the Women's Health Study who provided information on migraine and did not have diabetes at baseline. Our four exposure groups were migraine with aura, migraine without aura, past history of migraine and no history of migraine. Cox proportional hazards models were used to determine the hazard ratio for incident T2D.
Among the 38,620 women included in this study, 5062 (13.1%) women had migraine, of whom 2014 (39.8%) reported migraine with aura, and 2087 (5.4%) women had a past history of migraine. During a mean of 14.6 years of follow-up, there were 3032 cases of incident T2D. After adjustment for confounders, the hazard ratio (95% confidence interval) for developing diabetes was 1.06 (0.91-1.24) for women with migraine with aura, 1.01 (0.89-1.16) for women with migraine without aura, and 1.13 (0.98-1.30) for women with a past history of migraine compared with women with no history of migraine.
Results of this prospective study in women do not support an association between migraine and incident T2D.
先前评估糖尿病患病率与偏头痛状态之间关系的横断面研究得出了相互矛盾的结果。我们在一个成年女性队列中研究了偏头痛与 2 型糖尿病（T2D）发病之间的关系。
在妇女健康研究的参与者中进行前瞻性队列研究，这些参与者提供了偏头痛信息，且基线时无糖尿病。我们的四个暴露组为有先兆偏头痛、无先兆偏头痛、既往偏头痛史和无偏头痛史。使用 Cox 比例风险模型确定 T2D 发病的风险比。
在这项研究纳入的 38620 名女性中，有 5062 名（13.1%）女性患有偏头痛，其中 2014 名（39.8%）报告有先兆偏头痛，2087 名（5.4%）女性有既往偏头痛史。在平均 14.6 年的随访期间，有 3032 例新发 T2D 病例。在调整混杂因素后，与无偏头痛史的女性相比，有先兆偏头痛女性（95%置信区间：1.06，0.91-1.24）、无先兆偏头痛女性（95%置信区间：1.01，0.89-1.16）和既往偏头痛史女性（95%置信区间：1.13，0.98-1.30）发生糖尿病的风险比无显著差异。
这项针对女性的前瞻性研究结果不支持偏头痛与新发 T2D 之间存在关联。
