Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.
Cephalalgia. 2012 Oct;32(13):963-71. doi: 10.1177/0333102412455708. Epub 2012 Aug 8.
Some cross-sectional studies have suggested an association between migraine and increased body weight. However, prospective data on the association are lacking.
We conducted a prospective cohort study among 19,162 participants in the Women's Health Study who had a body mass index (BMI) of 18.5- <25 kg/m(2) at baseline. Migraine was self-reported by standardized questionnaires. Main outcome measures were incident overweight (BMI ≥ 25 kg/m(2)), incident obesity (BMI ≥ 30 kg/m(2)) and mean weight change. Age- and multivariable-adjusted hazard ratios (HRs) were calculated for the association between migraine and incident overweight and obesity. Differences in weight change were evaluated by analysis of covariance (ANCOVA).
A total of 3,483 (18.2%) women reported any migraine history. After 12.9 years of follow-up, 7916 incident overweight and 730 incident obesity cases occurred. Migraineurs had multivariable-adjusted HRs (95% confidence interval) of 1.11 (1.05-1.17) for becoming overweight and 1.00 (0.83-1.19) for becoming obese. These associations remained stable after censoring for chronic diseases and were similar according to migraine aura status. Multivariable-adjusted mean weight change from baseline to the end of study was +4.7 kg for migraineurs and +4.4 kg for women without migraine (p = 0.02).
Results of this large prospective study of middle-aged women do not indicate a consistent association between migraine and incident overweight, obesity or relevant weight gain.
一些横断面研究表明偏头痛与体重增加之间存在关联。然而，缺乏前瞻性数据。
我们对妇女健康研究中的 19162 名参与者进行了前瞻性队列研究，这些参与者在基线时的体重指数（BMI）为 18.5-<25kg/m(2)。偏头痛通过标准化问卷自行报告。主要结局指标是超重（BMI≥25kg/m(2)）、肥胖（BMI≥30kg/m(2)）和体重变化的发生率。使用年龄和多变量调整后的风险比（HR）计算偏头痛与超重和肥胖发生率之间的相关性。通过协方差分析（ANCOVA）评估体重变化的差异。
共有 3483 名（18.2%）女性报告有任何偏头痛病史。随访 12.9 年后，发生超重的病例为 7916 例，肥胖的病例为 730 例。偏头痛患者的多变量调整后的 HR（95%置信区间）分别为超重 1.11（1.05-1.17）和肥胖 1.00（0.83-1.19）。在慢性疾病和偏头痛先兆状态的情况下进行 censoring 后，这些关联仍然稳定。从基线到研究结束时，偏头痛患者的平均体重变化为+4.7kg，而无偏头痛患者的平均体重变化为+4.4kg（p=0.02）。
这项针对中年女性的大型前瞻性研究结果表明，偏头痛与超重、肥胖或相关体重增加之间没有一致的关联。
