Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai 200032, China.
Chem Commun (Camb). 2010 Sep 14;46(34):6285-7. doi: 10.1039/c0cc01073a. Epub 2010 Aug 9.
The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated tetrahydroisoquinoline derivatives were prepared by employing this method. It constitutes the first example of direct trifluoromethylation of tertiary amines.
发展了无过渡金属条件下过氧化苯甲酰（BPO）促进的叔胺的氧化官能化反应。该方法可制备各种 1-三氟甲基四氢异喹啉衍生物。这构成了叔胺直接三氟甲基化的首例实例。
