Fetal & Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, Stollery Children's Hospital, Women's & Children's Health Research Institute, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
Scand J Immunol. 2010 Sep;72(3):189-97. doi: 10.1111/j.1365-3083.2010.02437.x.
'Neonatal' lupus erythematosus (NLE) describes a clinical spectrum of cardiac and non-cardiac abnormalities observed in neonates and foetuses whose mothers have the auto-antibodies anti-SSA/Ro (anti-Ro) and anti-SSB/La (anti-La). Of the cardiac abnormalities, congenital AVB is the most common cardiovascular abnormality found in affected foetuses and infants. Many other cardiovascular manifestations of NLE have been more recently recognized including atrial and ventricular arrhythmias and other conduction abnormalities, myocarditis, cardiomyopathy often with endocardiofibroelastosis and structural heart disease, particularly valvar lesions. In this report, the spectrum of cardiovascular manifestations observed in foetuses and infants with NLE are reviewed and the pathogenesis, diagnosis and clinical outcomes are briefly discussed.
新生儿狼疮红斑（NLE）描述了一类在其母亲具有抗 SSA/ Ro（抗 Ro）和抗 SSB/ La（抗 La）自身抗体的新生儿和胎儿中观察到的心脏和非心脏异常的临床谱。在心脏异常中，先天性房室传导阻滞是受影响胎儿和婴儿中最常见的心血管异常。最近还认识到 NLE 的许多其他心血管表现，包括房性和室性心律失常以及其他传导异常、心肌炎、心肌病，常伴有心内膜纤维弹性组织增生和结构性心脏病，特别是瓣膜病变。在本报告中，回顾了 NLE 胎儿和婴儿中观察到的心血管表现谱，并简要讨论了其发病机制、诊断和临床转归。
