Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Box 110, Hills Rd, Cambridge CB2 0QQ, UK.
Hypertension. 2010 Oct;56(4):591-7. doi: 10.1161/HYPERTENSIONAHA.110.156950. Epub 2010 Aug 9.
Ageing exerts differential effects on arterial stiffness and wave reflections. However, the impact of cardiovascular risk factors on arterial stiffness and wave reflections and, particularly, how such effects are influenced by ageing has not been assessed within a single large population, covering a sufficiently wide age range. Therefore, we determined the extent to which age alters the impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections. Aortic stiffness and wave reflections were assessed in 4421 individuals (age range 18 to 92 years). When treated as continuous variables, clinic systolic, diastolic, and pulse pressures and glucose levels were independently associated with stiffness, and, with the exception of diastolic pressure, these associations were more marked in older individuals. In contrast, clinic systolic and diastolic pressures and smoking were independently associated with wave reflections, with stronger associations observed in younger individuals. The impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections is strongly dependent on age and is largely driven by blood pressure. Additional studies are required to assess the impact of these arterial measures on cardiovascular outcome within a single population.
衰老对动脉僵硬和波反射有不同的影响。然而，心血管危险因素对动脉僵硬和波反射的影响，特别是这些影响如何受到衰老的影响，尚未在一个涵盖足够广泛年龄范围的单一大型人群中进行评估。因此，我们确定了年龄在多大程度上改变了传统心血管危险因素对动脉僵硬和波反射的影响。在 4421 名个体（年龄范围 18 至 92 岁）中评估了主动脉僵硬和波反射。当作为连续变量处理时，诊所收缩压、舒张压和脉压以及血糖水平与僵硬独立相关，除了舒张压外，这些相关性在年龄较大的个体中更为明显。相比之下，诊所收缩压和舒张压以及吸烟与波反射独立相关，在年轻个体中观察到更强的相关性。传统心血管危险因素对动脉僵硬和波反射的影响强烈依赖于年龄，并且主要由血压驱动。需要进一步的研究来评估这些动脉指标在单一人群中的心血管结局的影响。
