CST 在端粒维持中的功能演变。
Evolution of CST function in telomere maintenance.
机构信息
Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH, USA.
出版信息
Cell Cycle. 2010 Aug 15;9(16):3157-65. doi: 10.4161/cc.9.16.12547. Epub 2010 Aug 26.
Abstract
Telomeres consist of an elaborate, higher-order DNA architecture, and a suite of proteins that provide protection for the chromosome terminus by blocking inappropriate recombination and nucleolytic attack. In addition, telomeres facilitate telomeric DNA replication by physical interactions with telomerase and the lagging strand replication machinery. The prevailing view has been that two distinct telomere capping complexes evolved, shelterin in vertebrates and a trimeric complex comprised of Cdc13, Stn1 and Ten1 (CST) in yeast. The recent discovery of a CST-like complex in plants and humans raises new questions about the composition of telomeres and their regulatory mechanisms in multicellular eukaryotes. In this review we discuss the evolving functions and interactions of CST components and their contributions to chromosome end protection and DNA replication.
摘要
端粒由复杂的高级 DNA 结构和一系列蛋白质组成，这些蛋白质通过阻止不合适的重组和核酶攻击，为染色体末端提供保护。此外，端粒通过与端粒酶和滞后链复制机制的物理相互作用，促进端粒 DNA 的复制。长期以来的观点是，两种不同的端粒加帽复合物进化而来，脊椎动物中的庇护素和酵母中的由 Cdc13、Stn1 和 Ten1（CST）组成的三聚体复合物。最近在植物和人类中发现了 CST 样复合物，这引发了关于多细胞真核生物中端粒的组成及其调控机制的新问题。在这篇综述中，我们讨论了 CST 成分的不断演变的功能和相互作用，以及它们对染色体末端保护和 DNA 复制的贡献。
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