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用于检测脑组织中非洲狂犬病病毒的快速免疫诊断试剂盒的评估。

Evaluation of a rapid immunodiagnostic test kit for detection of African lyssaviruses from brain material.

机构信息

Department of Microbiology and Plant Pathology, University of Pretoria, Pretoria, 0002 South Africa.

出版信息

Onderstepoort J Vet Res. 2009 Jun;76(2):257-62. doi: 10.4102/ojvr.v76i2.50.

DOI:10.4102/ojvr.v76i2.50
PMID:20698445
Abstract

A rapid immunodiagnostic test kit was evaluated against a selection of isolates of lyssavirus genotypes occurring in Africa. The test was carried out in parallel comparison with the fluorescent antibody test (FAT) and isolates representing previously established phylogenetic groups from each genotype were included. The specificity of the rapid immunodiagnostic test compared favourably with the FAT and was found to detect all representatives of genotypes 1, 2, 3 and 4 in brain samples of either field cases or suckling mouse brain inoculates.

摘要

一种快速免疫诊断试剂盒针对在非洲发生的几种狂犬病病毒基因型的分离株进行了评估。该检测与荧光抗体检测（FAT）平行进行，包括了来自每个基因型的先前已建立的系统发生组的分离株。与 FAT 相比，快速免疫诊断检测的特异性更好，并且发现它可以检测到来自现场病例或乳鼠脑接种物的 1、2、3 和 4 型基因型的所有代表。

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