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一项关于成人血液系统恶性肿瘤与高压架空电力线路关系的病例对照研究。

A case/control study of adult haematological malignancies in relation to overhead powerlines.

作者信息

Youngson J H, Clayden A D, Myers A, Cartwright R A

机构信息

Department of Epidemiology and Social Oncology, University of Manchester, UK.

出版信息

Br J Cancer. 1991 Jun;63(6):977-85. doi: 10.1038/bjc.1991.214.

Abstract

A population based case control study of adult haematological malignancy and distance from, and magnetic fields associated with, overhead (OH) power lines has been carried out in the North West and Yorkshire regions of England. Three-thousand, one hundred and forty-four cases with histologically proven disease were entered into the study. One control per case, matched for age, sex, year of diagnosis and health district of residence, was selected from hospital discharges. Seven per cent of cases and controls lived near to OH power lines as defined by the study protocol. The measure of exposure used was the calculated magnetic field strength at each of these addresses due to maximum load currents carried by OH power lines in the 5 years preceding diagnosis. The odds ratio (OR) for living within 50 m of an OH line was 1.29 with a 95% Confidence Interval (CI) of 0.99-1.68 but a chi 2 test for trend with distance was not statistically significant. The analysis of calculated magnetic fields, did not produce any statistically odds ratios. The OR for magnetic fields greater than or equal to 0.1 mG was 1.03 (95% CI 0.81 1.32). Analysis of magnetic fields greater than or equal to 3.0 mG gave an OR of 1.87 (95% CI 0.79 4.42), but this result is based on small numbers. No evidence was found for confounding by the type of dwelling which was used as a partial surrogate for socio-economic status.

摘要

在英格兰的西北部和约克郡地区,开展了一项基于人群的病例对照研究,研究对象为成人血液系统恶性肿瘤与距架空(OH)电力线的距离及相关磁场之间的关系。3144例经组织学确诊的病例纳入了该研究。从医院出院记录中为每个病例选取一名对照,对照在年龄、性别、诊断年份和居住的健康区方面与病例匹配。按照研究方案的定义,7%的病例和对照居住在靠近OH电力线的地方。所采用的暴露测量指标是根据诊断前5年OH电力线承载的最大负载电流计算出的每个住址处的磁场强度。居住在距OH线路50米范围内的比值比(OR)为1.29,95%置信区间(CI)为0.99 - 1.68,但距离趋势的卡方检验无统计学显著性。对计算出的磁场进行分析,未得出任何具有统计学意义的比值比。磁场强度大于或等于0.1毫高斯(mG)时的OR为1.03(95% CI 0.81 - 1.32)。对磁场强度大于或等于3.0 mG进行分析,得出的OR为1.87(95% CI 0.79 - 4.42),但该结果基于少量样本。未发现以居住类型作为社会经济地位部分替代指标存在混杂效应的证据。

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