Davis Daniel P, Peay Jeremy, Sise Michael J, Kennedy Frank, Simon Fred, Tominaga Gail, Steele John, Coimbra Raul
Department of Emergency Medicine, UC San Diego, San Diego, California, USA.
J Trauma. 2010 Aug;69(2):294-301. doi: 10.1097/TA.0b013e3181dc6c7f.
Emergent endotracheal intubation (ETI) is considered the standard of care for patients with severe traumatic brain injury (TBI). However, recent evidence suggests that the procedure may be associated with increased mortality, possibly reflecting inadequate training, suboptimal patient selection, or inappropriate ventilation.
To explore prehospital ETI in patients with severe TBI using a novel application of Trauma Score and Injury Severity Score methodology.
Patients with moderate-to-severe TBI (head Abbreviated Injury Scale score 3+) were identified from our county trauma registry. Demographic information, pre-resuscitation vital signs, and injury severity scores were used to calculate a probability of survival for each patient. The relationship between outcome and prehospital ETI, provider type (air vs. ground), and ventilation status were explored using observed survival-predicted survival and the ratio of unexpected survivors/deaths.
A total of 11,000 patients were identified with complete data for this analysis. Observed and predicted survivals were similar for both intubated and nonintubated patients. The ratio of unexpected survivors/deaths increased and observed survival exceeded predicted survival for intubated patients with lower predicted survival values. Both intubated and nonintubated patients transported by air medical crews had better outcomes than those transported by ground. Both hypo- and hypercapnia were associated with worse outcomes in intubated but not in nonintubated patients.
Prehospital intubation seems to improve outcomes in more critically injured TBI patients. Air medical outcomes are better than predicted for both intubated and nonintubated TBI patients. Iatrogenic hyper- and hypoventilations are associated with worse outcomes.
紧急气管插管(ETI)被认为是重度创伤性脑损伤(TBI)患者的标准治疗方法。然而,最近的证据表明,该操作可能与死亡率增加有关,这可能反映出培训不足、患者选择欠佳或通气不当。
使用创伤评分和损伤严重程度评分方法的一种新应用,探讨重度TBI患者的院前ETI。
从我们县的创伤登记处识别出中度至重度TBI(头部简明损伤量表评分3+)患者。使用人口统计学信息、复苏前生命体征和损伤严重程度评分来计算每位患者的生存概率。使用观察到的生存-预测生存以及意外幸存者/死亡比例,探讨结局与院前ETI、提供者类型(空中与地面)和通气状态之间的关系。
总共识别出11000例患者有完整数据用于此分析。插管患者和未插管患者的观察到的生存和预测生存相似。对于预测生存值较低的插管患者,意外幸存者/死亡比例增加,且观察到的生存超过预测生存。由空中医疗机组转运的插管患者和未插管患者的结局均优于由地面转运的患者。低碳酸血症和高碳酸血症在插管患者中均与较差的结局相关,但在未插管患者中并非如此。
院前插管似乎能改善伤情更严重的TBI患者的结局。对于插管和未插管的TBI患者,空中医疗的结局均优于预测。医源性通气过度和通气不足与较差的结局相关。