Parums D V, Choudhury R P, Shields S A, Davies A H
Nuffield Department of Pathology and Bacteriology, University of Oxford.
Br J Urol. 1991 Jun;67(6):564-8. doi: 10.1111/j.1464-410x.1991.tb15216.x.
During ureterolysis in a patient with "idiopathic retroperitoneal fibrosis", fresh samples of peri-ureteric and peri-aortic tissue were obtained. An abdominal CT scan confirmed the peri-aortic distribution of the inflammation associated with advanced abdominal aortic atherosclerosis. Histology confirmed the presence of fibrosis and a variable chronic inflammatory cell infiltrate. Monoclonal antibodies were used to identify the inflammatory cells. B and T lymphocytes were present with the majority of T lymphocytes of the T helper phenotype. The majority of lymphocytes and macrophages and most vascular endothelial cells were HLA-DR positive. Ki67 and BerH2 staining was found in B cells and T helper cells, indicating that these cells were proliferating and activated. These findings compare with the characterisation of inflammatory cells associated with "inflammatory aneurysms" and with the inflammatory cells present in the spectrum of inflammation seen as a complication of advanced atherosclerosis--conditions known as "chronic peri-aortitis". It is suggested that our findings support the view that idiopathic retroperitoneal fibrosis represents clinical chronic peri-aortitis seen in an undilated aorta.
在一名患有“特发性腹膜后纤维化”的患者进行输尿管松解术期间，获取了输尿管周围和主动脉周围组织的新鲜样本。腹部CT扫描证实了与晚期腹主动脉粥样硬化相关的炎症在主动脉周围的分布。组织学检查证实存在纤维化和不同程度的慢性炎性细胞浸润。使用单克隆抗体来识别炎性细胞。存在B淋巴细胞和T淋巴细胞，其中大多数T淋巴细胞为辅助性T细胞表型。大多数淋巴细胞、巨噬细胞以及大多数血管内皮细胞HLA - DR呈阳性。在B细胞和辅助性T细胞中发现了Ki67和BerH2染色，表明这些细胞正在增殖和活化。这些发现与“炎性动脉瘤”相关炎性细胞的特征以及作为晚期动脉粥样硬化并发症所见炎症谱中存在的炎性细胞（即“慢性主动脉周围炎”）相比较。有人提出，我们的发现支持这样一种观点，即特发性腹膜后纤维化代表在未扩张主动脉中所见的临床慢性主动脉周围炎。
