Interdisciplinary Centre for Bioinformatics, University of Leipzig, Germany.
Bioinformatics. 2010 Oct 15;26(20):2641-2. doi: 10.1093/bioinformatics/btq437. Epub 2010 Aug 13.
CellSys is a modular software tool for efficient off-lattice simulation of growth and organization processes in multi-cellular systems in 2D and 3D. It implements an agent-based model that approximates cells as isotropic, elastic and adhesive objects. Cell migration is modeled by an equation of motion for each cell. The software includes many modules specifically tailored to support the simulation and analysis of virtual tissues including real-time 3D visualization and VRML 2.0 support. All cell and environment parameters can be independently varied which facilitates species specific simulations and allows for detailed analyses of growth dynamics and links between cellular and multi-cellular phenotypes.
CellSys is freely available for non-commercial use at http://msysbio.com/software/cellsys. The current version of CellSys permits the simulation of growing monolayer cultures and avascular tumor spheroids in liquid environment. Further functionality will be made available ongoing with published papers.
hoehme@izbi.uni-leipzig.de; dirk.drasdo@inria.fr
Supplementary data are available at Bioinformatics online.
CellSys 是一个用于在 2D 和 3D 中对多细胞系统中的生长和组织过程进行高效非格点模拟的模块化软件工具。它实现了一种基于代理的模型，将细胞近似为各向同性、弹性和粘性物体。细胞迁移通过每个细胞的运动方程进行建模。该软件包括许多专门为支持虚拟组织的模拟和分析而设计的模块，包括实时 3D 可视化和 VRML 2.0 支持。所有细胞和环境参数都可以独立变化，这便于进行特定于物种的模拟，并允许对生长动态和细胞与多细胞表型之间的联系进行详细分析。
CellSys 可在 http://msysbio.com/software/cellsys 上免费供非商业使用。CellSys 的当前版本允许在液体环境中模拟生长的单层培养物和无血管肿瘤球体。随着已发表论文的不断推进，将提供更多功能。
hoehme@izbi.uni-leipzig.de;dirk.drasdo@inria.fr
补充数据可在 Bioinformatics 在线获得。
