Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, 220 Kungdong, Yoosung-gu, Daejeon 305-764, Korea.
Vet Rec. 2010 Aug 14;167(7):245-9. doi: 10.1136/vr.c3611.
Two different combinations of anaesthetics were evaluated and compared in a prospective randomised crossover experimental study in pigs. One of the two combinations was administered intramuscularly to each of six Landrace x Yorkshire mixed-breed pigs. The combinations were: 2.2 mg/kg xylazine and 4.4 mg/kg tiletamine/zolazepam (2.2 mg/kg tiletamine plus 2.2 mg/kg zolazepam) (XTZ); and 0.04 mg/kg medetomidine and 4.4 mg/kg tiletamine/zolazepam (MTZ). The anaesthesia and recovery times, score for anaesthetic effect and cardiopulmonary parameters were recorded for each pig. Anaesthesia was successfully induced in all of the pigs. Both drug combinations provided smooth induction and good immobilisation, and their anaesthetic effects were similar. In both treatment groups, the mean heart rate decreased significantly five minutes after the drugs were administered and remained consistent for 70 minutes, with no significant difference between the XTZ and MTZ groups. However, there were differences in cardiopulmonary effects between the groups. The arterial pressure was significantly higher in the MTZ group than in the XTZ group. The initial hypertension associated with medetomidine was more marked than the initial hypertension associated with xylazine. Arterial oxygen partial pressure and arterial oxygen saturation decreased significantly from baseline in both groups. The respiratory rates and levels of blood gases were similar in both groups. Hypoventilation and hypoxaemia were observed in both groups. The scores for anaesthetic effect, induction time, anaesthesia time and recovery times were similar in the two groups.
在一项前瞻性随机交叉实验研究中，我们评估并比较了两种不同的麻醉组合在猪身上的效果。这两种组合中的每一种都以肌肉注射的方式施用于 6 头长白猪和大约克夏猪的杂种猪。这两种组合是：2.2 mg/kg 二甲噻嗪和 4.4 mg/kg 替来他明/唑拉西泮（2.2 mg/kg 替来他明加 2.2 mg/kg 唑拉西泮）（XTZ）；以及 0.04 mg/kg 美托咪定和 4.4 mg/kg 替来他明/唑拉西泮（MTZ）。每头猪的麻醉和恢复时间、麻醉效果评分和心肺参数都被记录下来。所有的猪都成功地诱导了麻醉。两种药物组合都能顺利诱导和良好地固定，麻醉效果相似。在两组治疗中，给药后 5 分钟，平均心率均显著下降，70 分钟内保持一致，XTZ 组和 MTZ 组之间无显著差异。然而，两组之间的心肺效应存在差异。MTZ 组的动脉压明显高于 XTZ 组。美托咪定引起的初始高血压比二甲噻嗪引起的初始高血压更明显。两组的动脉血氧分压和动脉血氧饱和度均较基线显著下降。两组的呼吸频率和血气水平相似。两组均出现通气不足和低氧血症。两组的麻醉效果评分、诱导时间、麻醉时间和恢复时间相似。
