Department of Veterinary Surgery, Northeast Agricultural University, Harbin 150030, China.
Vet Rec. 2010 Sep 25;167(13):489-92. doi: 10.1136/vr.c4458.
This study investigated the effects of a combination of tiletamine-zolazepam and xylazine plus tramadol (TZXT) and compared the efficacy of this combination with that of tiletaminezolazepam and xylazine (TZX) for providing anaesthesia in Chinese experimental miniature pigs. Fourteen healthy, eight-month-old miniature pigs of both sexes were immobilised with TZXT or TZX on two different occasions. The pigs' immobilisation and analgesia scores and baseline physiological parameters (heart rate, respiratory rate, non-invasive systolic, diastolic and mean arterial blood pressures, arterial haemoglobin oxygen saturation and rectal temperature) were determined before and five, 10, 30, 45, 60, 80 and 100 minutes after the administration of TZXT or TZX. Pigs in both groups became laterally recumbent within three minutes. Some physiological parameters were changed after administration of the drug combinations, but they remained within biologically acceptable limits and were not significantly different between the two treatments. The use of TZXT resulted in better induction time and quality of recovery compared with TZX, with higher scores for sedation, analgesia, muscle relaxation, posture and auditory response. The animals were much calmer during recovery after TZXT immobilisation.
本研究探讨了替来他明-唑拉西泮和二甲噻嗪联合曲马多（TZXT）的作用，并比较了该联合用药与替来他明-唑拉西泮和二甲噻嗪（TZX）在提供中国实验小型猪麻醉方面的效果。在两次不同的情况下，14 只健康的、八个月大的雌雄同体小型猪分别用 TZXT 或 TZX 进行固定。在给予 TZXT 或 TZX 之前和之后的 5、10、30、45、60、80 和 100 分钟，测定猪的固定和镇痛评分以及基线生理参数（心率、呼吸频率、无创收缩压、舒张压和平均动脉血压、动脉血红蛋白氧饱和度和直肠温度）。两组中的猪在三分钟内均侧卧。给药后，一些生理参数发生了变化，但仍在可接受的生物学范围内，两种治疗方法之间没有显著差异。与 TZX 相比，TZXT 的诱导时间和恢复质量更好，镇静、镇痛、肌肉松弛、姿势和听觉反应的评分更高。TZXT 固定后，动物在恢复过程中更加平静。
