克霉唑500毫克阴道栓剂或氟康唑150毫克胶囊治疗阴道念珠菌病后阴道菌群的比较。
Comparison of vaginal flora after treatment with a clotrimazole 500 mg vaginal pessary or a fluconazole 150 mg capsule for vaginal candidosis.
作者信息
Boag F C, Houang E T, Westrom R, McCormack S M, Lawrence A G
机构信息
Department of Genitourinary Medicine, John Hunter Clinic, London, UK.
出版信息
Genitourin Med. 1991 Jun;67(3):232-4. doi: 10.1136/sti.67.3.232.
The effect of antifungal therapy on the vaginal microbial flora was studied in 23 patients suffering from culture-positive, symptomatic vaginal candidosis. They were randomly allocated to receive either a 500 mg clotrimazole vaginal pessary or a 150 mg fluconazole capsule. Quantitative microbiological examination was carried out on samples of vaginal secretions obtained prior, and at intervals up to 10 days after, treatment. No significant difference was found in the vaginal flora before or after therapy in individual patients or between the treatment groups. In patients with C glabrata or C krusei, the yeasts persisted longer in the vagina with poorer response to either of the medications.
对23例培养阳性、有症状的阴道念珠菌病患者研究了抗真菌治疗对阴道微生物菌群的影响。她们被随机分配接受500毫克克霉唑阴道栓剂或150毫克氟康唑胶囊治疗。在治疗前以及治疗后长达10天的间隔时间采集阴道分泌物样本进行定量微生物学检查。在个体患者中或治疗组之间，治疗前后的阴道菌群均未发现显著差异。对于光滑念珠菌或克柔念珠菌感染的患者，阴道内的酵母菌持续存在时间更长，对任何一种药物的反应均较差。
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