• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

单次口服150毫克氟康唑后患者血浆和阴道分泌物中的氟康唑水平以及阴道念珠菌病感染的根除率。

Fluconazole levels in plasma and vaginal secretions of patients after a 150-milligram single oral dose and rate of eradication of infection in vaginal candidiasis.

作者信息

Houang E T, Chappatte O, Byrne D, Macrae P V, Thorpe J E

机构信息

Queen Charlotte's and Chelsea Hospital for Women, London, United Kingdom.

出版信息

Antimicrob Agents Chemother. 1990 May;34(5):909-10. doi: 10.1128/AAC.34.5.909.

DOI:10.1128/AAC.34.5.909
PMID:2360828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171718/
Abstract

Mean peak concentrations of fluconazole in plasma and vaginal secretions of females after a 150-mg single oral dose were shown to be 2.82 micrograms/ml and 2.43 micrograms/g, respectively. Our results indicate that clinically efficacious concentrations of fluconazole in vaginal secretions are easily achieved after this single oral dose.

摘要

女性单次口服150毫克氟康唑后，血浆和阴道分泌物中的平均峰值浓度分别显示为2.82微克/毫升和2.43微克/克。我们的结果表明，单次口服该剂量后，阴道分泌物中很容易达到氟康唑的临床有效浓度。

相似文献

1
Fluconazole levels in plasma and vaginal secretions of patients after a 150-milligram single oral dose and rate of eradication of infection in vaginal candidiasis.单次口服150毫克氟康唑后患者血浆和阴道分泌物中的氟康唑水平以及阴道念珠菌病感染的根除率。
Antimicrob Agents Chemother. 1990 May;34(5):909-10. doi: 10.1128/AAC.34.5.909.
2
Oral fluconazole for vaginal candidiasis.口服氟康唑治疗阴道念珠菌病。
Am Fam Physician. 1996 Sep 15;54(4):1337-40, 1345-6.
3
Fluconazole concentrations in breast milk.
Pediatr Infect Dis J. 1995 Mar;14(3):235-6. doi: 10.1097/00006454-199503000-00012.
4
Guideline: vulvovaginal candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis).指南：外阴阴道念珠菌病（德国医学专业协会编号015/072），S2k（不包括慢性黏膜皮肤念珠菌病）
Mycoses. 2015 Mar;58 Suppl 1:1-15. doi: 10.1111/myc.12292.
5
Glucose in vaginal secretions before and after oral glucose tolerance testing in women with and without recurrent vulvovaginal candidiasis.有和没有复发性外阴阴道念珠菌病的女性在口服葡萄糖耐量试验前后阴道分泌物中的葡萄糖情况。
Obstet Gynecol. 2006 Dec;108(6):1432-7. doi: 10.1097/01.AOG.0000246800.38892.fc.
6
Vaginal pH and microbiota during fluconazole maintenance treatment for recurrent vulvovaginal candidosis (RVVC).氟康唑维持治疗复发性外阴阴道念珠菌病（RVVC）期间的阴道 pH 值和微生物群。
Diagn Microbiol Infect Dis. 2020 Jun;97(2):115024. doi: 10.1016/j.diagmicrobio.2020.115024. Epub 2020 Feb 14.
7
Comparison of vaginal flora after treatment with a clotrimazole 500 mg vaginal pessary or a fluconazole 150 mg capsule for vaginal candidosis.克霉唑500毫克阴道栓剂或氟康唑150毫克胶囊治疗阴道念珠菌病后阴道菌群的比较。
Genitourin Med. 1991 Jun;67(3):232-4. doi: 10.1136/sti.67.3.232.
8
Efficacy of the clinical agent VT-1161 against fluconazole-sensitive and -resistant Candida albicans in a murine model of vaginal candidiasis.临床药物VT-1161在阴道念珠菌病小鼠模型中对氟康唑敏感和耐药白色念珠菌的疗效。
Antimicrob Agents Chemother. 2015 Sep;59(9):5567-73. doi: 10.1128/AAC.00185-15. Epub 2015 Jun 29.
9
Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis.光滑念珠菌在糖尿病合并外阴阴道念珠菌病患者中的患病率及其与口服氟康唑相比对硼酸阴道栓剂的反应。
Diabetes Care. 2007 Feb;30(2):312-7. doi: 10.2337/dc06-1469.
10
Comparison of clotrimazole, fluconazole and itraconazole in vaginal candidiasis.克霉唑、氟康唑和伊曲康唑治疗阴道念珠菌病的比较。
Br J Clin Pract. 1995 Mar-Apr;49(2):65-6.

引用本文的文献

1
Antifungal susceptibility testing and determination of local epidemiological cut-off values for species isolated from women with vulvovaginal candidiasis.从外阴阴道念珠菌病女性患者中分离出的菌株的抗真菌药敏试验及当地流行病学截断值的确定。
Microbiol Spectr. 2025 Mar 4;13(3):e0248824. doi: 10.1128/spectrum.02488-24. Epub 2025 Jan 23.
2
causes recurrent vulvovaginal candidiasis by forming morphologically disparate biofilms on the human vaginal epithelium.通过在人类阴道上皮形成形态各异的生物膜引发复发性外阴阴道念珠菌病。
Biofilm. 2023 Oct 22;6:100162. doi: 10.1016/j.bioflm.2023.100162. eCollection 2023 Dec 15.
3
A post-mortem analysis of tenofovir, lamivudine, efavirenz and fluconazole penetration in female genital tissues.替诺福韦、拉米夫定、依非韦伦和氟康唑在女性生殖组织中的渗透的死后分析。
J Antimicrob Chemother. 2022 Oct 28;77(11):3180-3186. doi: 10.1093/jac/dkac300.
4
Transient Mitochondria Dysfunction Confers Fungal Cross-Resistance against Phagocytic Killing and Fluconazole.短暂的线粒体功能障碍赋予真菌抗吞噬杀伤和氟康唑的交叉耐药性。
mBio. 2021 Jun 29;12(3):e0112821. doi: 10.1128/mBio.01128-21. Epub 2021 Jun 1.
5
Anti-biofilm activity of chlorhexidine digluconate against Candida albicans vaginal isolates.洗必泰葡萄糖酸盐对白色念珠菌阴道分离株的抗生物膜活性。
PLoS One. 2020 Sep 17;15(9):e0238428. doi: 10.1371/journal.pone.0238428. eCollection 2020.
6
Developmental changes of fluconazole clearance in neonates and infants in relation to ontogeny of glomerular filtration rate: literature review and data analysis.新生儿和婴儿中氟康唑清除率与肾小球滤过率个体发育的关系及发育变化：文献综述与数据分析
J Pharm Health Care Sci. 2018 Mar 20;4:5. doi: 10.1186/s40780-018-0103-5. eCollection 2018.
7
Comparing the Recurrence of Vulvovaginal Candidiasis in Patients Undergoing Prophylactic Treatment with Probiotic and Placebo During the 6 Months.比较 6 个月内预防性使用益生菌和安慰剂治疗的患者中复发性外阴阴道念珠菌病的情况。
Probiotics Antimicrob Proteins. 2016 Sep;8(3):130-3. doi: 10.1007/s12602-016-9218-x.
8
Efficacy of the clinical agent VT-1161 against fluconazole-sensitive and -resistant Candida albicans in a murine model of vaginal candidiasis.临床药物VT-1161在阴道念珠菌病小鼠模型中对氟康唑敏感和耐药白色念珠菌的疗效。
Antimicrob Agents Chemother. 2015 Sep;59(9):5567-73. doi: 10.1128/AAC.00185-15. Epub 2015 Jun 29.
9
Candidiasis (vulvovaginal).念珠菌病（外阴阴道）
BMJ Clin Evid. 2015 Mar 16;2015:0815.
10
Tissue penetration of antifungal agents.抗真菌药物的组织穿透性。
Clin Microbiol Rev. 2014 Jan;27(1):68-88. doi: 10.1128/CMR.00046-13.

本文引用的文献

1
Gas chromatographic method for the determination of fluconazole, a novel antifungal agent, in human plasma and urine.
J Chromatogr. 1986 Nov 28;383(1):179-86. doi: 10.1016/s0378-4347(00)83458-1.
2
A comparison of fluconazole and ketoconazole in the oral treatment of vaginal candidiasis; report of a double-blind multicentre trial.
Eur J Obstet Gynecol Reprod Biol. 1988 Dec;29(4):305-13. doi: 10.1016/0028-2243(88)90071-8.
3
Single-dose oral fluconazole in the treatment of vaginal candidosis.
Ann N Y Acad Sci. 1988;544:561-3. doi: 10.1111/j.1749-6632.1988.tb40452.x.
4
Fluconazole in the management of oropharyngeal candidosis in a predominantly HIV antibody-positive group of patients.
J Med Vet Mycol. 1988 Feb;26(1):67-71. doi: 10.1080/02681218880000081.