Penning Renske, van Nuland Merel, Fliervoet L A L, Olivier Berend, Verster Joris C
Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacology, Utrecht University, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands.
Curr Drug Abuse Rev. 2010 Jun;3(2):68-75. doi: 10.2174/1874473711003020068.
Research on human subjects analyzing blood and urine samples determined biological correlates that may explain the pathology of alcohol hangover. These analyses showed that concentrations of various hormones, electrolytes, free fatty acids, triglycerides, lactate, ketone bodies, cortisol, and glucose were not significantly correlated with reported alcohol hangover severity. Also, markers of dehydration (e.g., vasopressin) were not significantly related to hangover severity. Some studies report a significant correlation between blood acetaldehyde concentration and hangover severity, but most convincing is the significant relationship between immune factors and hangover severity. The latter is supported by studies showing that hangover severity may be reduced by inhibitors of prostaglandin synthesis. Several factors do not cause alcohol hangover but can aggravate its severity. These include sleep deprivation, smoking, congeners, health status, genetics and individual differences. Future studies should more rigorously study these factors as well as biological correlates to further elucidate the pathology of alcohol hangover.
对人体受试者进行的分析血液和尿液样本的研究确定了可能解释酒精宿醉病理的生物学关联。这些分析表明，各种激素、电解质、游离脂肪酸、甘油三酯、乳酸、酮体、皮质醇和葡萄糖的浓度与报告的酒精宿醉严重程度没有显著相关性。此外，脱水标志物（如抗利尿激素）与宿醉严重程度没有显著关系。一些研究报告血液乙醛浓度与宿醉严重程度之间存在显著相关性，但最有说服力的是免疫因素与宿醉严重程度之间的显著关系。后者得到了一些研究的支持，这些研究表明前列腺素合成抑制剂可能会减轻宿醉严重程度。有几个因素不会导致酒精宿醉，但会加重其严重程度。这些因素包括睡眠不足、吸烟、同系物、健康状况、遗传和个体差异。未来的研究应该更严格地研究这些因素以及生物学关联，以进一步阐明酒精宿醉的病理。
