Stephens Richard, Holloway Kara, Grange James A, Owen Lauren, Jones Kate, Kruisselbrink Darren
Keele University, Keele, Staffordshire, ST5 5BG, Newcastle, UK.
Psychology Department, University of Central Lancashire (UCLAN), Fylde Rd, PR1 2HE, Preston, UK.
Psychopharmacology (Berl). 2017 Jun;234(12):1795-1802. doi: 10.1007/s00213-017-4585-x. Epub 2017 Mar 16.
Positive family history of alcohol use disorder (FHP), a variable associated with propensity for alcohol use disorder (AUD), has been linked with elevated hangover frequency and severity, after controlling for alcohol use. This implies that hangover experiences may be related to AUD. However, inadequate control of alcohol consumption levels, low alcohol dose and testing for hangover during the intoxication phase detract from these findings. Here, we present further data pertinent to understanding the relationship between family history and alcohol hangover.
Study 1 compared past year hangover frequency in a survey of 24 FHP and 118 family history negative (FHN) individuals. Study 2 applied a quasi-experimental naturalistic approach assessing concurrent hangover severity in 17 FHP and 32 FHN individuals the morning after drinking alcohol. Both studies applied statistical control for alcohol consumption levels.
In Study 1, both FHP status and estimated blood alcohol concentration on the heaviest drinking evening of the past month predicted the frequency of hangover symptoms experienced over the previous 12 months. In Study 2, estimated blood alcohol concentration the previous evening predicted hangover severity but FHP status did not.
FHP, indicating familial risk for AUD, was not associated with concurrent hangover severity but was associated with increased estimates of hangover frequency the previous year.
酒精使用障碍家族史（FHP）是一种与酒精使用障碍（AUD）倾向相关的变量，在控制饮酒量后，它与宿醉频率和严重程度的升高有关。这意味着宿醉经历可能与酒精使用障碍有关。然而，对酒精消费水平控制不足、酒精剂量低以及在醉酒阶段检测宿醉会影响这些研究结果。在此，我们提供进一步的数据，以有助于理解家族史与酒精性宿醉之间的关系。
研究1在一项对24名有酒精使用障碍家族史者和118名无家族史者的调查中比较了过去一年的宿醉频率。研究2采用准实验自然主义方法，在饮酒后的次日早晨评估17名有酒精使用障碍家族史者和32名无家族史者的同时期宿醉严重程度。两项研究均对酒精消费水平进行了统计控制。
在研究1中，酒精使用障碍家族史状态以及过去一个月中饮酒量最大的晚上的估计血液酒精浓度，都能预测过去12个月内经历的宿醉症状频率。在研究2中，前一晚的估计血液酒精浓度能预测宿醉严重程度，但酒精使用障碍家族史状态则不能。
表明酒精使用障碍家族风险的酒精使用障碍家族史，与同时期宿醉严重程度无关，但与上一年宿醉频率的增加估计值有关。
