Joiris E, Bastin B, Thornback J R
R/D Imaging, Medgenix Group, Fleurus, Belgium.
Int J Rad Appl Instrum B. 1991;18(3):353-6. doi: 10.1016/0883-2897(91)90131-4.
A new method of labelling of antibodies with technetium-99m is described. The antibody or fragment is derivatized by iminothiolane. Ligand exchange from a labile technetium complex such as TcO(GLU)2- results in greater than 90% of the technetium labelling the antibody. This method appears to be equally applicable to antibodies and fragments.
