Cross J P, Reynolds G E, Mackintosh C G, Griffin J F
Microbiology Department, Medical School, University of Otago, Dunedin, New Zealand.
J Am Vet Med Assoc. 1991 May 15;198(10):1785-8.
After intradermal injection of bovine purified derivative (PPD), increases in plasma fibrinogen concentration and plasma viscosity developed in red deer (Cervus elaphus) with a history of tuberculosis caused by Mycobacterium bovis. Serum haptoglobin concentrations were also found to increase under similar circumstances. The increases were reproducible and did not appear to be related to mustering, stress, or the handling associated with injection of PPD. A significant (P less than 0.05) direct relationship was found between the increase in plasma fibrinogen concentration and various markers of bovine tuberculosis infection, such as stimulation of lymphocyte transformation in response to bovine PPD and the diameter of intradermal tuberculin skin test reactions. A stronger correlation (P less than 0.01) was found with the volume of intradermal tuberculin skin test reactivity, and the strongest correlation (P less than 0.001) was with the presence of circulating antibovine PPD antibody.
对有牛分枝杆菌引起的结核病病史的马鹿（ Cervus elaphus ）进行牛纯化衍生物（PPD）皮内注射后，其血浆纤维蛋白原浓度和血浆粘度升高。在类似情况下，血清触珠蛋白浓度也会升高。这些升高是可重复的，并且似乎与聚集、应激或与PPD注射相关的处理无关。血浆纤维蛋白原浓度的升高与牛结核病感染的各种标志物之间存在显著（P小于0.05）的直接关系，例如对牛PPD的淋巴细胞转化刺激和皮内结核菌素皮肤试验反应的直径。与皮内结核菌素皮肤试验反应性的体积有更强的相关性（P小于0.01），与循环抗牛PPD抗体的存在相关性最强（P小于0.001）。
