Biochemistry Laboratory, Galway University Hospital, Newcastle Road, Galway, Ireland.
Ir J Med Sci. 2011 Mar;180(1):115-9. doi: 10.1007/s11845-010-0550-y. Epub 2010 Aug 17.
Increasing attention has been focused on diseases associated with ageing, as the mean age of the population in developed countries increases. Vitamin D and parathyroid hormone play key roles in calcium homeostasis, which is integral to skeletal health.
To assess the vitamin D status of healthy, community dwelling, middle-aged and older females.
General biochemistry and bone profiles, including ALP, PTH and 25(OH)D, were determined.
Of 143 healthy white women receiving no supplementation or bone modifying treatments, 47% were vitamin D insufficient (<50 nmol/L) and only 4% were sufficient for the time of year. There was no statically significant correlation between age and 25(OH)D concentrations; neither was there a statistically significant seasonal variation in 25(OH)D levels noted.
Vitamin D status should be assessed more often in middle-aged and older females. Expected age-related and seasonal variations in 25(OH)D levels were not confirmed in this study.
随着发达国家人口平均年龄的增长，与衰老相关的疾病受到了越来越多的关注。维生素 D 和甲状旁腺激素在钙稳态中发挥着关键作用，钙稳态是骨骼健康的重要组成部分。
评估健康、居住在社区的中年和老年女性的维生素 D 状况。
测定了一般生化和骨谱，包括碱性磷酸酶、甲状旁腺激素和 25（OH）D。
在 143 名未接受补充或骨骼修饰治疗的健康白人女性中，47%的人维生素 D 不足（<50nmol/L），只有 4%的人在一年中的这个时候足够。年龄与 25（OH）D 浓度之间没有统计学上的显著相关性；也没有注意到 25（OH）D 水平的季节性变化有统计学意义。
应更频繁地评估中年和老年女性的维生素 D 状况。本研究未证实预期的与年龄相关和季节性的 25（OH）D 水平变化。
