Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, Ghent, Belgium.
Adv Drug Deliv Rev. 2011 Aug 14;63(9):748-61. doi: 10.1016/j.addr.2011.03.014. Epub 2011 Apr 12.
Polymeric multilayer capsules have emerged as a novel drug delivery platform. These capsules are fabricated through layer-by-layer sequential deposition of polymers onto a sacrificial core template followed by the decomposition of this core yielding hollow capsules. The resulting nanometer thin membrane is permselective, allowing diffusion of water and ions but excluding larger molecules. Moreover, the sequential fabrication procedure allows a precise fine-tuning of the capsules' physicochemical and biological properties. These properties have put polymeric multilayer capsules under major attention in the field of drug delivery. In this review we focus on polymeric multilayer capsule mediated delivery of biotechnological macromolecular drugs such as peptides, proteins and nucleic acids.
聚合物多层胶囊作为一种新型的药物输送平台已经出现。这些胶囊是通过在牺牲核模板上逐层顺序沉积聚合物，然后分解该核来制备的，从而得到中空胶囊。得到的纳米薄膜具有选择透过性，允许水和离子扩散，但排斥较大的分子。此外，顺序制造过程允许对胶囊的物理化学和生物学性质进行精确的微调。这些特性使聚合物多层胶囊在药物输送领域受到广泛关注。在这篇综述中，我们重点介绍了聚合物多层胶囊介导的生物技术大分子药物（如肽、蛋白质和核酸）的递药。
