Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Curr Opin Cardiol. 2010 Nov;25(6):541-5. doi: 10.1097/HCO.0b013e32833e6e13.
Acute aortic dissection is a disease that is often a challenge to diagnose. Early and immediate diagnosis is important for initiation of treatment and improved survival. Despite recent advances in imaging methods to diagnose the disease, biochemical methods are not available.
Biomarkers that might be useful for the biochemical detection of acute aortic dissection have been recently described, such as assays for the circulating proteins, smooth muscle myosin heavy chain, creatine kinase BB-isozyme, calponin (smooth muscle troponin) and elastin. C-reactive protein and D-dimer have also been shown to be useful.
Biomarker-assisted diagnosis of acute aortic dissection would be helpful in detecting this acute catastrophic aortic disease, which still remains a challenge to diagnose. Although recent progress in development of biomarkers has been made, there is no widely accepted strategy. Available biomarkers such as D-dimer may play an assistive role in the meantime.
急性主动脉夹层是一种通常难以诊断的疾病。早期和及时的诊断对于开始治疗和提高生存率非常重要。尽管最近在影像学方法上有了进展，但还没有生化方法。
最近描述了一些可能对急性主动脉夹层的生化检测有用的生物标志物，例如循环蛋白、平滑肌肌球蛋白重链、肌酸激酶 BB 同工酶、钙调蛋白（平滑肌肌钙蛋白）和弹性蛋白的检测。C 反应蛋白和 D-二聚体也被证明是有用的。
生物标志物辅助诊断急性主动脉夹层有助于检测这种急性灾难性主动脉疾病，目前这仍然是一个诊断难点。尽管在生物标志物的开发方面取得了最近的进展，但还没有被广泛接受的策略。目前可用的生物标志物，如 D-二聚体，可能会在此期间发挥辅助作用。
