黏附的空间组织：力依赖性调节及其在组织形态发生中的功能。
Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis.
机构信息
Institute of Science and Technology Austria, Klosterneuburg, Austria.
出版信息
EMBO J. 2010 Aug 18;29(16):2753-68. doi: 10.1038/emboj.2010.182.
Abstract
Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force-mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis.
摘要
整合素和钙黏着蛋白介导的黏附对于细胞和组织形态发生至关重要，使细胞和组织能够在不失去完整性的情况下改变形状。主要在细胞培养中的研究表明，通过黏附结构的力介导调节其分子组成来实现机械感觉。黏附位点的特定分子组成又决定了它们的信号活性和动态重组。在这里，我们将回顾黏附位点如何响应机械刺激，以及来自不同黏附位点的时空调节信号如何控制细胞迁移和组织形态发生。
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